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SML0091

L-Dopa ethyl ester

≥98% (HPLC), Dopaminergic acent, powder

Synonym(s):

3,4-Dihydroxy-L-phenylalanine ethyl ester, 3-Hydroxy-L-tyrosine ethyl ester, Etilevodopa, L-Dopa ethyl ester, L-Dopa-Et, Levodopa ethyl ester, O-Ethyl-DOPA, TV-1203

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5 mg
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$145.00
25 mg
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$580.00

About This Item

Empirical Formula (Hill Notation):
C11H15NO4
CAS Number:
37178-37-3
Molecular Weight:
225.24
UNSPSC Code:
12352108
PubChem Substance ID:
329825151
NACRES:
NA.77
MDL number:
MFCD00871210
Assay:
≥98% (HPLC)
Form:
powder

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Product Name

L-Dopa ethyl ester, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D +15 to +19°, c = 1 in methanol ([α]/D)

color

white to tan

solubility

H2O: ≥12 mg/mL at warmed to 60 °C

storage temp.

2-8°C

SMILES string

CCOC(=O)[C@@H](N)Cc1ccc(O)c(O)c1

InChI

1S/C11H15NO4/c1-2-16-11(15)8(12)5-7-3-4-9(13)10(14)6-7/h3-4,6,8,13-14H,2,5,12H2,1H3/t8-/m0/s1

InChI key

NULMGOSOSZBEQL-QMMMGPOBSA-N

Gene Information

human ... DRD3(1814)

Application

L-Dopa ethyl ester has been used to study the protective effects of piperlongumine (PLG) on rotenone-induced Parkinson disease (PD).

Biochem/physiol Actions

L-Dopa ethyl ester is a prodrug of levodopa that has greater gastric solubility. The drug is rapidly hydrolyzed to levodopa by nonspecific esterases in the gastrointestinal tract. L-Dopa ethyl ester (etilevodopa)-carbidopa treatment was well tolerated but did not demonstrate better efficacy compared with standard levodopa-carbidopa treatment. L-Dopa ethyl ester should have a significant brain penetration following an administration by injection.
L-Dopa ethyl ester is prodrug of levodopa that has greater gastric solubility; antiparkinsonian agent
L-Dopa ethyl ester (L-Dopa) is a dopamine replacement drug. It is used as a potent therapeutic for Parkinson disease (PD). L-Dopa has some long-term side effects, such as the deterioration of motor function.

Features and Benefits

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item
L04000001361009D1507
L-Dopa ethyl ester ≥98% (HPLC)

Sigma-Aldrich

SML0091

L-Dopa ethyl ester

Levodopa European Pharmacopoeia (EP) Reference Standard

L0400000

Levodopa

Levodopa United States Pharmacopeia (USP) Reference Standard

USP

1361009

Levodopa

L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride solid

Sigma-Aldrich

D1507

L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride

form

powder

form

-

form

-

form

solid

assay

≥98% (HPLC)

assay

-

assay

-

assay

-

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

200

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

H2O: ≥12 mg/mL at warmed to 60 °C

solubility

-

solubility

-

solubility

-

color

white to tan

color

-

color

-

color

white to off-white

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H319

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000564919
0000557972
0000564919
0000557972
0000520767

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Global Trade Item Number

SKUGTIN
SML0091-25MG04061832074733
SML0091-5MG04061837076794

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