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SML0103

AMTB hydrate

≥98% (HPLC)

Synonym(s):

N-(3-aminopropyl)-2-[(3-methylphenyl)methoxy]-N-(2-thienylmethyl)-benzamide hydrochloride (1:1) hyclate

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Size/SKUAvailabilityPrice
5 mg

Estimated to ship onDecember 17, 2026fromMILWAUKEE

$150.00
25 mg
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$481.00

About This Item

Empirical Formula (Hill Notation):
C23H26N2O2S·HCl · xH2O
CAS Number:
Molecular Weight:
430.99 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated

$150.00


Estimated to ship onDecember 17, 2026Details


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Quality Segment

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to tan

solubility

DMSO: ≥10 mg/mL

storage temp.

2-8°C

SMILES string

O=C(C1=C(OCC2=C(C)C=CC=C2)C=CC=C1)N(CCCN)CC3=CC=CS3.Cl.O

InChI

1S/C23H26N2O2S.ClH.H2O/c1-18-8-2-3-9-19(18)17-27-22-12-5-4-11-21(22)23(26)25(14-7-13-24)16-20-10-6-15-28-20;;/h2-6,8-12,15H,7,13-14,16-17,24H2,1H3;1H;1H2

InChI key

RTYVTAQFASBIDN-UHFFFAOYSA-N

Application

AMTB hydrate has been used as an inhibitor of transient receptor potential cation channel, subfamily melastatin, member 8 (TRPM8) in breast cancer cells and murine T cells.

Biochem/physiol Actions

AMTB is a TRPM8 ion channel blocker
AMTB is a TRPM8-selective antagonist with no cross reactivity to TRPV1 or 4. The pIC50 of icilin activation of TRPM8 is 6.23 i.v. administration of AMTB reduced the frequency of rhythmic contractions in volume-loaded bladder and inhibited blood pressure and visceromotor reflex responses to bladder distention.
AMTB is a 2-benzyloxy-benzoic acid amide derivative, which also inhibits voltage-gated sodium channels (Nav) and their isoforms.

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This Item
CB_88052067
description

≥98% (HPLC)

description

88052067, IHW Number: 9067

form

powder

form

-

assay

≥98% (HPLC)

assay

-

Quality Level

100

Quality Level

-

storage temp.

2-8°C

storage temp.

-

storage condition

desiccated

storage condition

-

solubility

DMSO: ≥10 mg/mL

solubility

-


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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