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SML0116

GW788388 Hydrate

≥98% (HPLC), TGFβ signalling inhibitor, powder

Synonym(s):

4-{4-[3-(Pyridin-2-yl)-1H-pyrazol-4-yl]-pyridin-2-yl}-N-(tetrahydro-2H-pyran-4-yl)benzamide hydrate

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$178.00

About This Item

Empirical Formula (Hill Notation):
C25H23N5O2 · xH2O
Molecular Weight:
425.48 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$178.00


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Product Name

GW788388 Hydrate, ≥98% (HPLC)

Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥8 mg/mL

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

O.O=C(NC1CCOCC1)c2ccc(cc2)-c3cc(ccn3)-c4c[nH]nc4-c5ccccn5

InChI

1S/C25H23N5O2.H2O/c31-25(29-20-9-13-32-14-10-20)18-6-4-17(5-7-18)23-15-19(8-12-27-23)21-16-28-30-24(21)22-3-1-2-11-26-22;/h1-8,11-12,15-16,20H,9-10,13-14H2,(H,28,30)(H,29,31);1H2

InChI key

VZRJMBZMFKADGR-UHFFFAOYSA-N

Biochem/physiol Actions

GW788388 is a potent selective inhibitor of TGF-beta type I receptor [activin receptor-like kinase 5 (ALK5)]. GW788388 is orally available with a half-life of approximately 4 hours.
TGFβ1 (ALK5) inhibitor; Potent, selective inhibitor of TGFβ signalling in vitro and renal fibrosis in vivo

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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This Item
S4317SML0511SML2822
description

≥98% (HPLC)

description

≥98% (HPLC), powder

description

≥98% (HPLC)

description

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

300

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: ≥8 mg/mL

solubility

DMSO: soluble 10 mg/mL, H2O: insoluble

solubility

DMSO: 10 mg/mL (clear solution)

solubility

DMSO: 2 mg/mL, clear

originator

GlaxoSmithKline

originator

GlaxoSmithKline

originator

-

originator

-


Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable



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