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SML0141

Trilostane

≥98% (HPLC), 3β-hydroxysteroid dehydrogenase inhibitor, powder

Synonym(s):

(4α,5α,17β)-3,17-dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile

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10 mg
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$143.00
$121.55
50 mg
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$594.00

About This Item

Empirical Formula (Hill Notation):
C20H27NO3
CAS Number:
13647-35-3
Molecular Weight:
329.43
NACRES:
NA.77
PubChem Substance ID:
329825189
UNSPSC Code:
51111800
EC Number:
237-133-0
MDL number:
MFCD00199295
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

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Product Name

Trilostane, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥17 mg/mL

storage temp.

2-8°C

SMILES string

C[C@]12CC[C@H]3[C@@H](CC[C@@]45O[C@@H]4C(O)=C(C[C@]35C)C#N)[C@@H]1CC[C@@H]2O

InChI

1S/C20H27NO3/c1-18-7-6-14-12(13(18)3-4-15(18)22)5-8-20-17(24-20)16(23)11(10-21)9-19(14,20)2/h12-15,17,22-23H,3-9H2,1-2H3/t12-,13-,14-,15-,17+,18-,19+,20+/m0/s1

InChI key

KVJXBPDAXMEYOA-CXANFOAXSA-N

Gene Information

human ... HSD3B2(3284)

General description

Trilostane inhibits the production of adrenal steroids, such as cortisol and aldosterone. It is used to treat aldosteronism.

Application

Trilostane was used to inhibit the activity of 3β-hydroxysteroid dehydrogenase in mouse ovary.[1]
Trilostane has been used to evaluate its capability to regulate the sex-dependent differences in the lipopolysaccharide (LPS)-induced inflammatory responses of astrocytes.

Biochem/physiol Actions

Inhibitor of 3 β-hydroxysteroid dehydrogenase
Trilostane is an inhibitor of 3 β-hydroxysteroid dehydrogenase (3-β-HSD or delta 5-delta 4-isomerase), an essential enzyme for the biosynthesis of all classes of hormonal steroids. It has been used in the treatment of Cushing′s syndrome for stopping the production of cortisol, and is currently approved for dogs in the US, but is still a human drug in the UK and other countries. It is being investigated as a possible treatment for both breast cancer and prostate cancer to prevent the synthesis of estrogens and androgens from endogenous precursors. It has also been used to inhibit endogenous production of progesterone in research studies.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item
SML0438A7755SML0147
Trilostane ≥98% (HPLC)

Sigma-Aldrich

SML0141

Trilostane

Mibolerone ≥98% (HPLC)

Sigma-Aldrich

SML0438

Mibolerone

5α-Androstane-3α,17β-diol

Sigma-Aldrich

A7755

5α-Androstane-3α,17β-diol

Drospirenone ≥98% (HPLC)

Sigma-Aldrich

SML0147

Drospirenone

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (TLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

storage temp.

2-8°C

solubility

DMSO: ≥17 mg/mL

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

methanol: 19.60-20.40 mg/mL, clear, colorless

solubility

DMSO: ≥15

color

white to tan

color

white to beige

color

-

color

white to tan

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000536341
0000503428
0000536341
0000503428
0000082991

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Related Content

Nuclear Receptors (Steroids)

We offers many products related to Nuclear Receptors (Steroids) for your research needs.

Nyssa J Reine
Clinical techniques in small animal practice, 22(1), 18-25 (2007-06-05)
Pituitary-dependent hyperadrenocorticism is a common endocrine disorder in dogs in the United States. Once a diagnosis is established, a decision must be made whether or not to pursue treatment, and if so, which medication to use. Historically, mitotane (Lysodren, o,p'-DDD
W A Burkhardt et al.
Domestic animal endocrinology, 40(3), 155-164 (2011-01-05)
Adrenal necrosis has been reported as a complication of trilostane application in dogs with hyperadrenocorticism. One suspicion was that necrosis results from the increase of adrenocorticotropic hormone (ACTH) during trilostane therapy. The aim of the current study was to assess
J R Helm et al.
Journal of veterinary internal medicine, 25(2), 251-260 (2011-03-01)
Trilostane is a recognized treatment for canine pituitary-dependent hyperadrenocorticism (PDH); however, its efficacy in dogs with adrenal-dependent hyperadrenocorticism (ADH) is unknown. To examine factors that might influence survival in the medical management of ADH, with particular emphasis on treatment selection.
View All Related Papers

Global Trade Item Number

SKUGTIN
SML0141-50MG04061832867878
SML0141-10MG04061832867861

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