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Trilostane

Name: Trilostane
Brand: SIGMA
Price: 148 USD
Availability: InStock

≥98% (HPLC), 3β-hydroxysteroid dehydrogenase inhibitor, powder

Synonym(s):

(4α,5α,17β)-3,17-dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile

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Size/SKU	Availability	Price
10 mg	Available to ship TODAYfromMILWAUKEE	$148.00
50 mg	Available to ship TODAYfromMILWAUKEE	$615.00

About This Item

Empirical Formula (Hill Notation):

C₂₀H₂₇NO₃

CAS Number:

13647-35-3

Molecular Weight:

329.43

NACRES:

NA.77

PubChem Substance ID:

329825189

UNSPSC Code:

51111800

EC Number:

237-133-0

MDL number:

MFCD00199295

Assay:

≥98% (HPLC)

Form:

powder

$148.00

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Properties

Product Name

Trilostane, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥17 mg/mL

storage temp.

2-8°C

SMILES string

C[C@]12CC[C@H]3[C@@H](CC[C@@]45O[C@@H]4C(O)=C(C[C@]35C)C#N)[C@@H]1CC[C@@H]2O

InChI

1S/C20H27NO3/c1-18-7-6-14-12(13(18)3-4-15(18)22)5-8-20-17(24-20)16(23)11(10-21)9-19(14,20)2/h12-15,17,22-23H,3-9H2,1-2H3/t12-,13-,14-,15-,17+,18-,19+,20+/m0/s1

InChI key

KVJXBPDAXMEYOA-CXANFOAXSA-N

Gene Information

human ... HSD3B2(3284)

Description

General description

Trilostane inhibits the production of adrenal steroids, such as cortisol and aldosterone. It is used to treat aldosteronism.

Application

Trilostane has been used to evaluate its capability to regulate the sex-dependent differences in the lipopolysaccharide (LPS)-induced inflammatory responses of astrocytes.

Trilostane was used to inhibit the activity of 3β-hydroxysteroid dehydrogenase in mouse ovary.

Biochem/physiol Actions

Inhibitor of 3 β-hydroxysteroid dehydrogenase

Trilostane is an inhibitor of 3 β-hydroxysteroid dehydrogenase (3-β-HSD or delta 5-delta 4-isomerase), an essential enzyme for the biosynthesis of all classes of hormonal steroids. It has been used in the treatment of Cushing′s syndrome for stopping the production of cortisol, and is currently approved for dogs in the US, but is still a human drug in the UK and other countries. It is being investigated as a possible treatment for both breast cancer and prostate cancer to prevent the synthesis of estrogens and androgens from endogenous precursors. It has also been used to inhibit endogenous production of progesterone in research studies.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item	C7971	231085	1703805
Sigma-Aldrich SML0141 Trilostane	Sigma-Aldrich C7971 Cilostamide	Sigma-Aldrich 231085 Cilostamide	USP 1703805 Tylosin
description ≥98% (HPLC)	description phosphodiesterase inhibitor	description A cell-permeable selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC₅₀ = 70 nM).	description United States Pharmacopeia (USP) Reference Standard
form powder	form powder	form solid	form -
assay ≥98% (HPLC)	assay ≥97% (HPLC)	assay ≥98% (TLC)	assay -
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level -
storage temp. 2-8°C	storage temp. -	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: ≥17 mg/mL	solubility DMSO: 20 mg/mL, clear, colorless to faintly yellow	solubility DMSO: 5 mg/mL	solubility -
color white to tan	color -	color white	color -

Pictograms

GHS08,GHS07

Signal Word

Warning

Hazard Codes

H315,H319,H361

Precautionary Statements

P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313

Hazard Classifications

Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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