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SML0152

AK-7

≥98% (HPLC)

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$112.00

About This Item

Empirical Formula (Hill Notation):
C19H21BrN2O3S
CAS Number:
420831-40-9
Molecular Weight:
437.35
NACRES:
NA.25
PubChem Substance ID:
329825200
UNSPSC Code:
12352200
MDL number:
MFCD03140195
Assay:
≥98% (HPLC)
Form:
powder

$112.00

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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥15 mg/mL

storage temp.

2-8°C

SMILES string

Brc1cccc(NC(=O)c2cccc(c2)S(=O)(=O)N3CCCCCC3)c1

InChI

1S/C19H21BrN2O3S/c20-16-8-6-9-17(14-16)21-19(23)15-7-5-10-18(13-15)26(24,25)22-11-3-1-2-4-12-22/h5-10,13-14H,1-4,11-12H2,(H,21,23)

InChI key

IYAYHZZWYNXHEQ-UHFFFAOYSA-N

General description

AK-7 (3-(1-azepanylsulfonyl)-N-(3-bromphenyl) benzamide) is a cell- and brain-permeable, selective SIRT2 (sirtuin 2) inhibitor.

Application

AK-7 has been used in cell culture and cell treatment.

Biochem/physiol Actions

AK-7 is a brain penetrant selective SIRT2 inhibitor. No inhibition of SIRT1 or SIRT3 detected.
Selective SIRT2 Inhibitor
Selective SIRT2 Inhibitor AK-7 is a brain penetrant selective SIRT2 inhibitor. No inhibition of SIRT1 or SIRT3 detected.
In neurons, the sirtuin 2 inhibitor AK-7 is neuroprotective in vitro and decreases polyglutamine inclusions and cholesterol levels. In mice, treatment with brain-permeable SIRT2 inhibitor AK-7 led to improved motor function, extended survival and decreased brain atrophy. AK-7 decreases the polyglutamine aggregation in R6/2 brain.

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This Item
CB_89071903SML0911
AK-7 ≥98% (HPLC)

Sigma-Aldrich

SML0152

AK-7

vibrant-m

AK-D

TAK-779 ≥98% (HPLC)

Sigma-Aldrich

SML0911

TAK-779

description

≥98% (HPLC)

description

NOTE: Both the cell line and DNA from the cell line may be available for this product. Please choose -1VL or VIAL for cells, or -DNA-5UG for DNA, 89071903, feline lung, Epithelial

description

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

assay

≥98% (HPLC)

form

powder

form

-

form

powder

Quality Level

100

Quality Level

-

Quality Level

100

storage temp.

2-8°C

storage temp.

−196°C

storage temp.

2-8°C

solubility

DMSO: ≥15 mg/mL

solubility

-

solubility

H2O: 3 mg/mL, clear (warmed)

color

white to tan

color

-

color

white to beige

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Codes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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