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SML0178

ARL-17477 dihydrochloride hydrate

≥98% (HPLC)

Synonym(s):

N-[4-[2-[[(3-chlorophenyl)methyl]amino]ethyl]phenyl]-2-thiophenecarboximidamide dihydrochloride hydrate

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$153.00

About This Item

Empirical Formula (Hill Notation):
C20H20ClN3S·2HCl · xH2O
CAS Number:
Molecular Weight:
442.83 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated

$153.00


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Quality Segment

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: ≥5 mg/mL

originator

AstraZeneca

storage temp.

2-8°C

SMILES string

O.Cl.Cl.Clc1cccc(CNCCc2ccc(NC(=N)c3cccs3)cc2)c1

InChI

1S/C20H20ClN3S.2ClH.H2O/c21-17-4-1-3-16(13-17)14-23-11-10-15-6-8-18(9-7-15)24-20(22)19-5-2-12-25-19;;;/h1-9,12-13,23H,10-11,14H2,(H2,22,24);2*1H;1H2

InChI key

QOPATWWWZNTSQF-UHFFFAOYSA-N

Application

ARL-17477 dihydrochloride hydrate may be used in cell signaling studies.

Biochem/physiol Actions

ARL-17477 dihydrochloride hydrate is a selective nNOS inhibitor
ARL-17477 is an nNOS specific inhibitor. The IC50 against rat nNOS is 35 nM and it has 100-fold selectivity over endothelial and inducible isoforms. ARL-17477 penetrates the brain, and reduces infarct size and reduces cerebral blood flow in several different rodent models of ischemic brain injury.

Features and Benefits

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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This Item
G5793SML0272SML0853
description

≥98% (HPLC)

description

>98% (HPLC), powder

description

≥98% (HPLC)

description

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

>98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage condition

desiccated

storage condition

desiccated

storage condition

desiccated

storage condition

-

solubility

H2O: ≥5 mg/mL

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: ≥5 mg/mL

solubility

H2O: 1 mg/mL, clear (warmed)


pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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