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| Size/SKU | Availability | Price |
|---|---|---|
25 mg | Please contact Customer Service for Availability | $582.00 $494.70 |
About This Item
Empirical Formula (Hill Notation):
C22H23N3O2S
CAS Number:
Molecular Weight:
393.50
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
$494.70
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Please contact Customer Service for Availability
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to tan
solubility
DMSO: ≥10 mg/mL
storage temp.
2-8°C
SMILES string
Cc1nccn1-c2ccc(Sc3cccc(c3)C4(CCOCC4)C(N)=O)cc2
InChI
1S/C22H23N3O2S/c1-16-24-11-12-25(16)18-5-7-19(8-6-18)28-20-4-2-3-17(15-20)22(21(23)26)9-13-27-14-10-22/h2-8,11-12,15H,9-10,13-14H2,1H3,(H2,23,26)
InChI key
VPTONMHDLLMOOV-UHFFFAOYSA-N
Application
CJ-13610 may be used to study 5-lipoxygenase-mediated cell signaling.
Biochem/physiol Actions
CJ-13,610 is a potent inhbititor of 5-lipoxygenase (5-LO) activity (IC50 = 70 nM).
CJ-13610 inhibits the biosynthesis of leukotriene B4 and regulates the IL-6 mRNA expression in macrophages. It reduces fibrosis and necroinflammation of liver in carbon tetrachloride-treated mice.[1]
Potent 5-lipoxygenase inhibitor
Features and Benefits
This compound is featured on the Leukotriene Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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This Item | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form powder | form powder | form powder | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| storage condition desiccated | storage condition - | storage condition - | storage condition desiccated |
| solubility DMSO: ≥10 mg/mL | solubility DMSO: 20 mg/mL, clear | solubility DMSO: 15 mg/mL, clear | solubility DMSO: ≥15 mg/mL |
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
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