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SML0204

MS-1020

≥98% (HPLC)

Synonym(s):

1-Hydroxy-N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)-2-naphtamide, 1-Hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-naphthalenecarboxamide

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Size/SKUAvailabilityPrice
25 mg

Available to ship TODAYfromMILWAUKEE

$285.00
$242.25

About This Item

Empirical Formula (Hill Notation):
C21H18N2O3
CAS Number:
Molecular Weight:
346.38
NACRES:
NA.77
UNSPSC Code:
12352202
Assay:
≥98% (HPLC)
Form:
powder

$242.25

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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥10 mg/mL at 60 °C

storage temp.

2-8°C

Application

MS-1020 may be used in JAK-3-mediated cell signaling studies.

Biochem/physiol Actions

MS-1020 is a selective JAK3 inhibitor
MS-1020 is an ATP-competitive, selective inhibitor of JAK3, thereby blocking downstream STAT signaling. MS-1020 binds directly with JAK3, blocking its catalytic activity. It suppressed IL-2-induced JAK3/STAT5 signaling but not prolactin-induced JAK2/STAT5 signaling. MS-1020 has also been shown to decreases cell survival by inducing apoptosis via downregulating anti-apoptotic gene expression.

Features and Benefits

This compound is featured on the JAKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item
SML0248SML0243M1824
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥97% (HPLC)

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥97% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: ≥10 mg/mL at 60 °C

solubility

DMSO: ≥5 mg/mL

solubility

DMSO: >5 mg/mL

solubility

DMSO: ≥10 mg/mL

color

white to tan

color

white to beige

color

white to beige

color

orange


pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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