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SML0205

Z-Pro-prolinal

≥98% (HPLC)

Synonym(s):

Cbz-Pro-Prolinal, N-Benzyloxycarbonyl-L-prolyl-L-prolinal, Phenylmethyl (2S)-2-[(2S)-2-formylpyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate, Z-Pro-Pro-CHO, Z-PP-CHO, Z-pro-pro-CHO, Z-prolyl-prolinal, ZPP

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$129.00
25 mg

Available to ship TODAYfromMILWAUKEE

$497.00

About This Item

Empirical Formula (Hill Notation):
C18H22N2O4
CAS Number:
Molecular Weight:
330.38
UNSPSC Code:
12352209
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated

$129.00


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Quality Segment

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to tan

solubility

DMSO: ≥10 mg/mL

storage temp.

−20°C

SMILES string

N2([C@@H](CCC2)C(=O)N3[C@@H](CCC3)C=O)C(=O)OCc1ccccc1

InChI

1S/C18H22N2O4/c21-12-15-8-4-10-19(15)17(22)16-9-5-11-20(16)18(23)24-13-14-6-2-1-3-7-14/h1-3,6-7,12,15-16H,4-5,8-11,13H2/t15-,16-/m0/s1

InChI key

ORZXYSPOAVJYRU-HOTGVXAUSA-N

Application

Z-Pro-prolinal was used to inhibit activation of rekallikrein in Prolylcarboxypeptidase assay in HUVECs. ZPP was also used in assays to identify enzymes important in the processing of angiotensin peptides in human glomerular endothelial cells.

Biochem/physiol Actions

Z-Pro-prolinal is a potent selective inhibitor of prolyl oligopeptidase (POP), also known as prolyl endopeptidase (PEP or PE).
Z-Pro-prolinal is a potent, selective inhibitor of Prolyl oligopeptidase (POP), also known as prolyl endopeptidase (PEP or PE). Ki = 1 nM.

POP has been connected to memory and mood through regulation of the brain levels of its peptide substrates, which include AVP, substance P, neurotensin and TRH and is a potential target in cognitive function, memory, and neurodegenerative disorders such as amnesia, Alzheimer′s disease, and depression. POP has recently been reported to be involved in the release of the tetrapeptide acetyl-N-Ser-Asp-Lys-Pro (Ac-SDKP) from its precursor, 43-mer thymosin β4 (Tβ4). Ac-SDKP is involved in hemopoietic stem cell differentiation, is pro-angiogenic and antifibrogenic.

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This Item
A2112C899996270
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥99.0% (TLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥99.0% (TLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

-

solubility

DMSO: ≥10 mg/mL

solubility

deionized water: ≥2 mg/mL

solubility

DMSO: 15 mg/mL, clear

solubility

-


pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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