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SML0213

MC2050 hydrate

≥98% (HPLC)

Synonym(s):

2-[2-(4-(2-pyridyl)-1-piperazinyl)ethylsulfanyl]-3H-quinazolin-4-one dihydrochloride hydrate

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Size/SKUAvailabilityPrice
5 mg

Estimated to ship TODAYfromMILWAUKEE

$144.00
$122.40
25 mg
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$771.00

About This Item

Empirical Formula (Hill Notation):
C19H21N5OS·2HCl · xH2O
Molecular Weight:
440.39 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$122.40

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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: ≥5 mg/mL at warmed to 60 °C

storage temp.

2-8°C

SMILES string

O.Cl.Cl.O=C1NC(SCCN2CCN(CC2)c3ccccn3)=Nc4ccccc14

InChI

1S/C19H21N5OS.2ClH.H2O/c25-18-15-5-1-2-6-16(15)21-19(22-18)26-14-13-23-9-11-24(12-10-23)17-7-3-4-8-20-17;;;/h1-8H,9-14H2,(H,21,22,25);2*1H;1H2

InChI key

LMZZPRHHBPFDGE-UHFFFAOYSA-N

Application

MC2050 hydrate may be used in cell signaling studies.

Biochem/physiol Actions

MC2050 is a PARP-1 inhibitor
MC2050 is a water-soluble PARP-1 inhibitor. The IC50 for inhibition of PARP-1 activity is 119 nM, compared to 1.8 μM for PARP-2. MC2050 inhibits apoptosis and blocks poly ADP-ribosylation of histone H1 in hydrogen peroxide treated SH-SY5Y neuroblastoma cells.

Features and Benefits

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item
SML0400PZ0159A8106
form

powder

form

powder

form

powder

form

solid

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

>98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

storage temp.

2-8°C

solubility

H2O: ≥5 mg/mL at warmed to 60 °C

solubility

DMSO: 5 mg/mL at warmed (clear solution)

solubility

H2O: ≥13 mg/mL

solubility

DMSO: >5 mg/mL, H2O: insoluble

color

white to beige

color

white to beige

color

white to tan

color

-


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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