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SML0263

PF-04217903

≥98% (HPLC)

Synonym(s):

4-[1-(6-Quinolinylmethyl)-1H-1,2,3-triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazole-1-ethanol methanesulfonate (1:1)

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Pack SizeSKUAvailabilityPrice
25 mg

Available to ship TODAYfromMILWAUKEE

$403.00

About This Item

Empirical Formula (Hill Notation):
C19H16N8O·CH3SO3H
CAS Number:
956906-93-7
Molecular Weight:
468.49
NACRES:
NA.77
PubChem Substance ID:
329825271
UNSPSC Code:
12352200
MDL number:
MFCD17392584
Assay:
≥98% (HPLC)
Form:
powder

$403.00

Available to ship TODAYDetails

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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: ≥5 mg/mL (warmed)

storage temp.

2-8°C

SMILES string

CS(O)(=O)=O.OCCn1cc(cn1)-c2cnc3nnn(Cc4ccc5ncccc5c4)c3n2

InChI

1S/C19H16N8O.CH4O3S/c28-7-6-26-12-15(9-22-26)17-10-21-18-19(23-17)27(25-24-18)11-13-3-4-16-14(8-13)2-1-5-20-16;1-5(2,3)4/h1-5,8-10,12,28H,6-7,11H2;1H3,(H,2,3,4)

InChI key

HBEMHKVWZJTVOC-UHFFFAOYSA-N

Gene Information

human ... MET(4233)

Application

PF-04217903 has been used as tyrosine-protein kinase Met (C-Met) selective inhibitor in Madin-Darby Canine kidney (MDCK) cells and NT2D1 non-seminoma cells.

Biochem/physiol Actions

PF-04217903 is a c-Met inhibitor.
PF-04217903 is a highly selective, potent inhibitor of the hepatocyte growth factor receptor c-Met. PF-04217903 inhibits endogenous, wild type c-Met in A549 human lung carcinoma cells with an IC50 of 4.8 nM. The compund displays 1000-fold selectivity against a panel of 208 other kinases.
PF-04217903 is an ATP-competitive inhibitor. It elicits antiangiogenic functionality. PF-04217903 inhibits c-Met phosphorylation in xenograft models leading to partial tumor growth suppression.

Features and Benefits

This compound is featured on the Met page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item
PZ0233SML1643SML0565
PF-04217903 ≥98% (HPLC)

Sigma-Aldrich

SML0263

PF-04217903

PF-06424439 ≥98% (HPLC)

Sigma-Aldrich

PZ0233

PF-06424439

AS2444697 ≥98% (HPLC)

Sigma-Aldrich

SML1643

AS2444697

MK-0343 ≥98% (HPLC)

Sigma-Aldrich

SML0565

MK-0343

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

room temp

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: ≥5 mg/mL (warmed)

solubility

H2O: 10 mg/mL, clear

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 10 mg/mL, clear

color

white to beige

color

white to light brown

color

white to beige

color

white to beige

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
022M4613V
0000074312

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Global Trade Item Number

SKUGTIN
SML0263-25MG04061832962856
SML0263-5MG04061832962863

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