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SML0305

3-Deazaneplanocin A hydrochloride

≥97% (HPLC), S-adenosylhomocysteine hydrolase inhibitor, powder

Synonym(s):

(-)-1-[(1R,4R,5S)-3-(Hydroxymethyl)-4,5-dihydroxy-2-cyclopenten-1-yl]4-aminoimidazo[4,5-c]pyridine hydrochloride, DZNep hydrochloride

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Size/SKUAvailabilityPrice
1 mg
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$521.00
5 mg
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$1,750.00

About This Item

Empirical Formula (Hill Notation):
C12H14N4O3 · HCl
CAS Number:
Molecular Weight:
298.73
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥97% (HPLC)
Form:
powder
Storage condition:
desiccated

$521.00


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Product Name

3-Deazaneplanocin A hydrochloride, ≥97% (HPLC)

Quality Segment

assay

≥97% (HPLC)

form

powder

optical activity

[α]/D -88 to -108°, c = 0.1 in water

storage condition

desiccated

color

white to beige

solubility

H2O: ≥5 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

Cl.Nc1nccc2n(cnc12)[C@@H]3C=C(CO)[C@@H](O)[C@H]3O

InChI

1S/C12H14N4O3.ClH/c13-12-9-7(1-2-14-12)16(5-15-9)8-3-6(4-17)10(18)11(8)19;/h1-3,5,8,10-11,17-19H,4H2,(H2,13,14);1H/t8-,10-,11+;/m1./s1

InChI key

UNSKMHKAFPRFTI-FDKLLANESA-N

General description

3-Deazaneplanocin A hydrochloride is a carbocyclic analog of adenosine. It has antimetastatic property. It is used to treat Ebola virus disease, gastric cancer, myeloma and lymphoma.

Application

3-Deazaneplanocin A hydrochloride has been used to test its effect on ovarian tumor progression. It has also been used as a S-adenosyl homocysteine hydrolase (SAH) inhibitor in c33A2 cells.
3-Deazaneplanocin A hydrochloride has been used to examine the potential involvement of autophagy and apoptosis in colorectal cancer (CRC) cells.

Biochem/physiol Actions

3-Deazaneplanocin A (DZNep) is an S-Adenosylhomocysteine Hydrolase inhibitor and histone methyltransferase EZH2 inhibitor. It switches on repressed tumor suppressor genes and induces apoptosis by inhibiting the expression of EZH2.
3-Deazaneplanocin A is an S-Adenosylhomocysteine Hydrolase inhibitor and histone methyltransferase EZH2 inhibitor.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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This Item
P4670P7412SML0474
description

≥97% (HPLC)

description

-

description

≥98% (TLC), powder

description

≥98% (HPLC)

assay

≥97% (HPLC)

assay

-

assay

≥98% (TLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

-

storage temp.

room temp

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

desiccated

solubility

H2O: ≥5 mg/mL

solubility

-

solubility

H2O: 50 mg/mL

solubility

H2O: 5 mg/mL (clear solution, warmed)


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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