Skip to Content
MilliporeSigma

Skip To

SML0329

Carcinine dihydrochloride

≥98% (HPLC)

Synonym(s):

β-Alanylhistamine dihydrochloride, 3-Amino-N-[2-(1H-imidazol-4-yl)ethyl]propanamide dihydrochloride, Alistin, Beta-Alanylhistamine dihydrochloride

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Size/SKUAvailabilityPrice
5 mg
Check Cart for Availability
$108.00
$91.80
25 mg
Check Cart for Availability
$421.00
$357.85

About This Item

Empirical Formula (Hill Notation):
C8H14N4O · 2HCl
CAS Number:
Molecular Weight:
255.14
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated

$91.80

List Price$108.00Save 15%
Web-Only Promotion

Check Cart for Availability

Request a Custom Order
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist


Quality Segment

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: >15 mg/mL

storage temp.

−20°C

SMILES string

Cl.Cl.NCCC(=O)NCCc1cnc[nH]1

InChI

1S/C8H14N4O.2ClH/c9-3-1-8(13)11-4-2-7-5-10-6-12-7;;/h5-6H,1-4,9H2,(H,10,12)(H,11,13);2*1H

InChI key

ZQTUNIWBUQUKAM-UHFFFAOYSA-N

General description

Carcinine, a natural peptide derivative, with a β-alanyl residue and a histamine, carries an imidazole ring. In mammals, carcinine is present in the brain, muscle, intestine and liver tissues.

Application

Carcinine dihydrochloride has been used to study its effects on dopaminergic neuron degeneration.

Biochem/physiol Actions

Carcinine (β-alanyl histamine) is a selective histamine H3 antagonist, 100-1000-fold selective for H3 over H2 and H1, that also functions as an antioxidant and as a chemical chaperone to reduce non-enzymatic glycation of proteins and maintain native folding of proteins.
Carcinine is a selective histamine H3 antagonist; antioxidant.
Carcinine can scavenge a toxic product, called 4-hydroxynonenal (4-HNE), obtained during lipid oxidation. It has a protective role from oxidative damage on photoreceptor cells. Carcinine also exhibits lipid-peroxidase activity.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
T0202SML1821SML0276
description

≥98% (HPLC)

description

≥98% (HPLC), solid

description

≥95% (HPLC)

description

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

form

powder

form

solid

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

solubility

H2O: >15 mg/mL

solubility

DMSO: >20 mg/mL, H2O: ≥5 mg/mL

solubility

H2O: 15 mg/mL, clear

solubility

H2O: >15 mg/mL

storage condition

desiccated

storage condition

desiccated, under inert gas

storage condition

-

storage condition

desiccated


pictograms

CorrosionExclamation mark

signalword

Danger

Hazard Classifications

Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library



Questions

Reviews

No rating value

Active Filters