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SML0332

Edelfosine

≥95% (HPLC), apoptosis inducer, powder

Synonym(s):

1-Octadecyl-2-methylglycero-3-phosphorylcholine, 4-Hydroxy-7-methoxy-N,N,N-trimethyl-3,5,9-Trioxa-4-phosphaheptacosan-1-aminium 4-oxide, ALP, ET 18-OCH3, ET-18-OMe, NSC 324368, NSC 343649, Racemic 1-O-octadecyl-2-O-methylglycero-3-phosphocholine, Ro 14-5243

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Size/SKUAvailabilityPrice
5 mg

Estimated to ship TODAYfromSAINT LOUIS

$166.00
25 mg

Estimated to ship TODAYfromSAINT LOUIS

$626.00

About This Item

Empirical Formula (Hill Notation):
C27H58NO6P
CAS Number:
70641-51-9
Molecular Weight:
523.73
UNSPSC Code:
12352200
PubChem Substance ID:
329825337
NACRES:
NA.77
MDL number:
MFCD00135190
Assay:
≥95% (HPLC)
Form:
powder

$166.00

Estimated to ship TODAYDetails

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Product Name

Edelfosine, ≥95% (HPLC)

Quality Segment

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

H2O: 15 mg/mL (clear solution)

shipped in

wet ice

storage temp.

−20°C

SMILES string

CCCCCCCCCCCCCCCCCCOCC(COP([O-])(=O)OCC[N+](C)(C)C)OC

InChI

1S/C27H58NO6P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-23-32-25-27(31-5)26-34-35(29,30)33-24-22-28(2,3)4/h27H,6-26H2,1-5H3

InChI key

MHFRGQHAERHWKZ-UHFFFAOYSA-N

General description

Edelfosine has anti-inflammatory, anti-autoimmune, antiparasitic and anti-viral properties. It stimulates eryptosis by cell shrinkage and cell membrane scrambling.

Application

Edelfosine has been used to treat human lung carcinoma A549 cells and study its effects on tuftelin 1 (TUFT1) expression. It is also used to evaluate the cell growth of MCF-7/M cells.

Biochem/physiol Actions

Edelfosine is a synthetic alkyl-lisophospholipid with anti-tumor activity.
Edelfosine is a synthetic alkyl-lisophospholipid with anti-tumor activity. The compound induces apoptosis in a variety of cancer cells. Edelfosine accumulates in the cell membrane, where it alters lipid composition and induces the co-clustering of lipid rafts and Fas/CD95 death receptor.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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This Item
341207SML041550866
Edelfosine ≥95% (HPLC)

Sigma-Aldrich

SML0332

Edelfosine

ET-18-OCH3 A cell-permeable and reversible cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells.

Sigma-Aldrich

341207

ET-18-OCH3

Alantolactone ≥98% (HPLC)

Sigma-Aldrich

SML0415

Alantolactone

[6]-Gingerol analytical standard

Supelco

50866

[6]-Gingerol

description

≥95% (HPLC)

description

A cell-permeable and reversible cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells.

description

≥98% (HPLC)

description

analytical standard

assay

≥95% (HPLC)

assay

≥95% (TLC)

assay

≥98% (HPLC)

assay

≥94.0% (HPLC)

form

powder

form

solid

form

powder

form

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

H2O: 15 mg/mL (clear solution)

solubility

ethanol: 5 mg/mL, chloroform: 50 mg/mL, DMSO: 5 mg/mL, water: soluble

solubility

DMSO: 15 mg/mL (clear solution)

solubility

-

shipped in

wet ice

shipped in

ambient

shipped in

-

shipped in

-

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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