This material is not reported as being light sensitive.
SML0443
SU-5402
≥98% (HPLC), powder, FGFR inhibitor
Synonym(s):
3-[4-Methyl-2-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrol-3-yl]-propionic acid, PF-02969207, PNU-0290908
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Check Cart for Availability | $146.00 |
25 mg | Check Cart for Availability | $577.00 |
About This Item
Empirical Formula (Hill Notation):
C17H16N2O3
CAS Number:
Molecular Weight:
296.32
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Product Name
SU-5402, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
color
light yellow to dark orange
solubility
DMSO: 10 mg/mL (clear solution)
storage temp.
−20°C
SMILES string
Cc1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1CCC(O)=O
InChI
1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-
InChI key
JNDVEAXZWJIOKB-JYRVWZFOSA-N
Application
SU5402 has been used as a fibroblast growth factor receptor inhibitor:
- in cell signalling experiments to stimulate cells for MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay
- to study its effect on the expression of osteogenic markers and expression of osteoprotegerin and RANKL (runt-related transcription factor(RUNX)-2
- to prepare a stock solution with DMSO (Dimethyl superoxide) for cell culture medium and also to co-treat embryos
- to study its effect on osteogenic markers.
Biochem/physiol Actions
SU-5402 is a FGFR antagonist and angiogenesis inhibitor.
SU-5402 is a FGFR antagonist; angiogenesis inhibitor.
SU-5402 has inhibitory effect on the action of tyrosine kinases. It competitively binds to the ATP-binding site on the fibroblast growth factor receptor (FGFR).
Features and Benefits
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
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This Item | |
|---|---|
| description ≥98% (HPLC) | description SU5402, CAS 215543-92-3, is a cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of FGFR1 (IC50 = 10-20 µM in the presence of 1 mM ATP). |
| assay ≥98% (HPLC) | assay ≥95% (HPLC) |
| form powder | form lyophilized solid |
| Quality Level 100 | Quality Level 200 |
| storage temp. −20°C | storage temp. 2-8°C |
| solubility DMSO: 10 mg/mL (clear solution) | solubility DMSO: 25 mg/mL |
| color light yellow to dark orange | color - |
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Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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