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SML0471

A22 hydrochloride

≥95% (HPLC), MreB inhibitor, powder

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Synonym(s):

MreB Perturbing Compound A22, S-(3,4-Dichlorobenzyl)isothiourea hydrochloride

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Size/SKUAvailabilityPrice
10 mg

Available to ship TODAYfromMILWAUKEE

$109.00
50 mg

Available to ship TODAYfromMILWAUKEE

$425.00

About This Item

Empirical Formula (Hill Notation):
C8H8Cl2N2S · HCl
CAS Number:
Molecular Weight:
271.59
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥95% (HPLC)
Form:
powder
Storage condition:
desiccated

$109.00

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Product Name

A22 hydrochloride, ≥95% (HPLC)

Quality Segment

assay

≥95% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL (clear solution, warmed)

storage temp.

2-8°C

SMILES string

Cl.NC(=N)SCc1ccc(Cl)c(Cl)c1

InChI

1S/C8H8Cl2N2S.ClH/c9-6-2-1-5(3-7(6)10)4-13-8(11)12;/h1-3H,4H2,(H3,11,12);1H

InChI key

VBJNMXMOMSWRDV-UHFFFAOYSA-N

Application

A22 hydrochloride has been used to study its anti-biofilm activity, antibacterial, cyto and genotoxic activities. It is also used as a MreB polymerization inhibitor to understand the role of MreB polymers in Candidatus Thiosymbion oneisti and Candidatus T. hypermnestrae division.

Biochem/physiol Actions

A22 is an inhibitor of MreB, an actin-like bacterial protein, and has been shown to act as an antiobiotic adjuvant.
A22 is an inhibitor of MreB, an actin-like bacterial protein, and has been shown to act as an antiobiotic adjuvant. A22 inhibition of MreB disrupts the bacterial actin cytoskeleton, which can cause an increase in cell permeability and altered transport. A22 has been shown to have synergistic effects with several antibiotics including novobiocin and rifampin in gram negative bacteria.

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This Item
475951R7532SML0399
description

≥95% (HPLC)

description

A cell-permeable isothiourea compound that specifically, rapidly and reversibly perturbs MreB function without affecting eukaryotic actin polymerization.

description

≥98% (HPLC)

description

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

solid

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

storage temp.

2-8°C

storage condition

desiccated

storage condition

OK to freeze, protect from light, desiccated (hygroscopic)

storage condition

desiccated

storage condition

desiccated

solubility

H2O: 2 mg/mL (clear solution, warmed)

solubility

water: 2 mg/mL, DMSO: 200 mg/mL

solubility

DMSO: >10 mg/mL, H2O: >2 mg/mL

solubility

H2O: 12 mg/mL (clear solution)


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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