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SML0474

(S)-Duloxetine hydrochloride

≥98% (HPLC), 5-HT and NA reuptake inhibitor, powder

Synonym(s):

(γS)-N-Methyl-γ-(1-naphthalenyloxy)-2-thiophenepropanamine hydrochloride, (+)-(S)-N-Methyl-γ-(1-naphthyloxy)-2-thiophenepropylamine hydrochloride, (+)-N-Methyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine hydrochloride, LY-248686 hydrochloride

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Size/SKUAvailabilityPrice
10 mg
Please contact Customer Service for Availability
$88.50
50 mg
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$362.00

About This Item

Empirical Formula (Hill Notation):
C18H19NOS · HCl
CAS Number:
136434-34-9
Molecular Weight:
333.88
UNSPSC Code:
12352200
PubChem Substance ID:
329825429
NACRES:
NA.77
MDL number:
MFCD06407958
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated

$88.50

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Product Name

(S)-Duloxetine hydrochloride, ≥98% (HPLC)

Quality Segment

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D +116 to +125°, c = 1 in methanol

storage condition

desiccated

color

white to beige

solubility

H2O: 5 mg/mL (clear solution, warmed)

storage temp.

room temp

SMILES string

Cl.CNCC[C@H](Oc1cccc2ccccc12)c3cccs3

InChI

1S/C18H19NOS.ClH/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16;/h2-10,13,17,19H,11-12H2,1H3;1H/t17-;/m0./s1

InChI key

BFFSMCNJSOPUAY-LMOVPXPDSA-N

Gene Information

General description

(S)-Duloxetine hydrochloride belongs to the class of serotonin and norepinephrine reuptake inhibitors. Duloxetine is a thiophene derivative. It is used to treat stress urinary incontinence, psychiatric and metabolic disorders. It is also used for treating diabetic peripheral neuropathic pain, fibromyalgia, chronic musculoskeletal and low back pain (LBP). Duloxetine is a cytochrome P450 2D6 (CYP2D6) inhibitor.

Application

(S)-Duloxetine hydrochloride has been used as an antidepressant in rats exposed to chronic mild stress (CMS).

Biochem/physiol Actions

Duloxetine hydrochloride is a dual serotonin/norepinephrine reuptake inhibitor (SNRI), widely used clinically as an antidepressant and anxiolytic.
Duloxetine hydrochloride is a dual serotonin/norepinephrine reuptake inhibitor (SNRI); antidepressant; anxiolytic.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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air sensitive

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This Item
Y0001453Y0001454PHR1865
(S)-Duloxetine hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML0474

(S)-Duloxetine hydrochloride

Duloxetine hydrochloride European Pharmacopoeia (EP) Reference Standard

Y0001453

Duloxetine hydrochloride

Duloxetine for system suitability European Pharmacopoeia (EP) Reference Standard

Y0001454

Duloxetine for system suitability

Duloxetine Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1865

Duloxetine Hydrochloride

description

≥98% (HPLC)

description

European Pharmacopoeia (EP) Reference Standard

description

European Pharmacopoeia (EP) Reference Standard

description

Pharmaceutical Secondary Standard; Certified Reference Material

assay

≥98% (HPLC)

assay

-

assay

-

assay

-

form

powder

form

-

form

-

form

powder

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

300

storage temp.

room temp

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-30°C

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

-

solubility

H2O: 5 mg/mL (clear solution, warmed)

solubility

-

solubility

-

solubility

-

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Codes

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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