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SML0493

T16Ainh-A01

≥95% (HPLC)

Synonym(s):

2-[(5-Ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]-acetamide

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Size/SKUAvailabilityPrice
10 mg
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$87.00
$90.10
50 mg
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$352.00

About This Item

Empirical Formula (Hill Notation):
C19H20N4O3S2
CAS Number:
Molecular Weight:
416.52
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥95% (HPLC)
Form:
powder

$90.10

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Quality Segment

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

room temp

SMILES string

CCc1c(C)nc(SCC(=O)Nc2nc(cs2)-c3ccc(OC)cc3)nc1O

InChI

1S/C19H20N4O3S2/c1-4-14-11(2)20-18(23-17(14)25)28-10-16(24)22-19-21-15(9-27-19)12-5-7-13(26-3)8-6-12/h5-9H,4,10H2,1-3H3,(H,20,23,25)(H,21,22,24)

InChI key

QSIYTNYMBWYHAA-UHFFFAOYSA-N

Application

T16Ainh-A01 has been used as an inhibitor of transmembrane protein 16A (TMEM16A).

Biochem/physiol Actions

T16Ainh-A01 is a selective TMEM16A calcium-activated chloride channel inhibitor that strongly inhibits chloride current in salivary gland cells. T16Ainh-A01 poorly inhibited total CaCC current in intestinal and airway epithelial cells, but blocked mainly an initial, agonist-stimulated transient chloride current. T16Ainh-A01 does not alter cytoplasmic calcium and has little effect on CFTR Cl- conductance.
T16Ainh-A01 is a selective TMEM16A calcium-activated chloride channel inhibitor...

Features and Benefits

This compound is featured on the Chloride Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item
613551SML0916C6617
description

≥95% (HPLC)

description

The TMEM16A Inhibitor, T16Ainh-A01 controls the biological activity of TMEM16A.

description

≥98% (HPLC)

description

≥98% (HPLC), solid

form

powder

form

powder

form

powder

form

solid

assay

≥95% (HPLC)

assay

≥97% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

room temp

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 100 mg/mL, clear, colorless

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 15 mg/mL

color

white to beige

color

off-white

color

white to beige

color

off-white


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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