Skip to Content
MilliporeSigma

Skip To

SML0541

7α,25-Dihydroxycholesterol

≥98% (HPLC), powder, GPR183 agonist

Synonym(s):

5-Cholesten-3β,7α,25-triol

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Size/SKUAvailabilityPrice
5 mg
Check Cart for Availability
$408.00
25 mg
Check Cart for Availability
$1,640.00

About This Item

Empirical Formula (Hill Notation):
C27H46O3
CAS Number:
Molecular Weight:
418.65
UNSPSC Code:
12352211
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$408.00


Check Cart for Availability

Request a Custom Order
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist


Product Name

7α,25-Dihydroxycholesterol, ≥98% (HPLC)

Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL (clear solution)

storage temp.

2-8°C

SMILES string

C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C27H46O3/c1-17(7-6-12-25(2,3)30)20-8-9-21-24-22(11-14-27(20,21)5)26(4)13-10-19(28)15-18(26)16-23(24)29/h16-17,19-24,28-30H,6-15H2,1-5H3/t17-,19+,20-,21+,22+,23-,24+,26+,27-/m1/s1

InChI key

BQMSKLCEWBSPPY-IKVTXIKFSA-N

Application

7α,25-Dihydroxycholesterol has been used as a ligand for G protein-coupled receptor 183 (Gpr183).

Biochem/physiol Actions

7α,25-Dihydroxycholesterol (7α,25-OHC) is a potent and selective endogenous ligand for the orphan GPCR receptor EBI2 (GPR183) with an EC50 value in the picomolar range. The newly discovered EBI2–oxysterol signalling pathway has been shown to have an important role in the adaptive immune response, including a role in driving immune cell migration. In vitro and in vivo studies showed that 7,25-OHC can serve as a chemokine directing migration of B cells, T cells and dendritic cells.
7α,25-Dihydroxycholesterol is a potent agonist of the orphan GPCR receptor EBI2 (GPR183); directs immune cell migration.
7α,25-Dihydroxycholesterol has an ability to block the early steps of T-cell activation.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
SML1648H1015
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98%

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98%

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

200

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

room temp

solubility

DMSO: 5 mg/mL (clear solution)

solubility

DMSO: 3 mg/mL, clear (warmed)

solubility

-

color

white to beige

color

white to beige

color

-


Still not finding the right product?

Explore all of our products under 7α,25-Dihydroxycholesterol


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library



Questions

  1. What the optimal dissolvent of the compound for in vivo mouse injection?

    1 answer
    1. This product is soluble in DMSO at a concentration of 5 mg/mL. This stock solution can then be diluted with aqueous solutions such as PBS. This product is not sterile and has not been tested for in vivo or in vitro use.

      Please see the link below to review articles that may offer additional information for mouse studies:
      https://www.sigmaaldrich.com/US/en/search/sml0541?focus=papers&page=1&perpage=30&sort=relevance&term=sml0541&type=citation_search.

      Helpful?

Reviews

No rating value

Active Filters