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SML0601

BPTES

≥95% (HPLC), powder, glutaminase GLS1 (KGA) inhibitor

Synonym(s):

Bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$162.00
25 mg

Available to ship TODAYfromMILWAUKEE

$614.00

About This Item

Empirical Formula (Hill Notation):
C24H24N6O2S3
CAS Number:
314045-39-1
Molecular Weight:
524.68
UNSPSC Code:
12352200
PubChem Substance ID:
329825569
NACRES:
NA.77
MDL number:
MFCD01079848
Assay:
≥95% (HPLC)
Form:
powder

$162.00

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Product Name

BPTES, ≥95% (HPLC)

Quality Segment

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(CC1=CC=CC=C1)NC2=NN=C(S2)CCSCCC3=NN=C(NC(CC4=CC=CC=C4)=O)S3

InChI

1S/C24H24N6O2S3/c31-19(15-17-7-3-1-4-8-17)25-23-29-27-21(34-23)11-13-33-14-12-22-28-30-24(35-22)26-20(32)16-18-9-5-2-6-10-18/h1-10H,11-16H2,(H,25,29,31)(H,26,30,32)

InChI key

MDJIPXYRSZHCFS-UHFFFAOYSA-N

Application

Bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide (BPTES) has been used as a glutaminase inhibitor.

Biochem/physiol Actions

BPTES is a selective inhibitor of Glutaminase GLS1 (KGA), which is found in the kidney and brain, and is positively regulated by myc and strongly expressed in many tumors and tumor cell lines. Glutaminase converts glutamine to glutamate, which is an important excitatory neurotransmitter in brain and can be further oxidized to α-ketoglutarate to feed the tricarboxylic acid (TCA) cycle and to glutathione, which is important for controlling the level of reactive oxygen species (ROS), particularly important for cancer cell growth. BPTES was found to slow growth of glioma cells. BPTES is a noncompetitive inhibitor with a Ki of 3 μM.
BPTES is a selective inhibitor of Glutaminase GLS1.
Vaccinia virus (VACV) requires glutamine metabolism for its optimal replication. Inhibition of glutaminolysis by bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide (BPTES) can be a potential method to treat poxvirus infections.

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This Item
W376177
BPTES ≥95% (HPLC)

Sigma-Aldrich

SML0601

BPTES

5-Methyl-2-hepten-4-one natural (US), ≥97%, mixture of isomers, FG

Sigma-Aldrich

W376177

5-Methyl-2-hepten-4-one

description

≥95% (HPLC)

description

natural (US), ≥97%, mixture of isomers, FG

assay

≥95% (HPLC)

assay

≥97%

form

powder

form

-

Quality Level

100

Quality Level

300

storage temp.

2-8°C

storage temp.

-

solubility

DMSO: 10 mg/mL, clear

solubility

-

color

white to beige

color

-

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Codes

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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