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SML0618

NSC697923

≥98% (HPLC)

Synonym(s):

2-Nitro-5-tosylfuran, 2-[(4-Methylphenyl)sulfonyl]-5-nitro-Furan

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$73.20
25 mg

Available to ship TODAYfromMILWAUKEE

$257.00

About This Item

Empirical Formula (Hill Notation):
C11H9NO5S
CAS Number:
Molecular Weight:
267.26
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$73.20


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

SMILES string

[S](=O)(=O)(c2[o]c(cc2)[N+](=O)[O-])c1ccc(cc1)C

InChI

1S/C11H9NO5S/c1-8-2-4-9(5-3-8)18(15,16)11-7-6-10(17-11)12(13)14/h2-7H,1H3

InChI key

GAUHIPWCDXOLCZ-UHFFFAOYSA-N

General description

NSC697923 stimulates apoptosis in p53 mutant neuroblastoma (NB) cells by triggering JNK (c-Jun N-terminal kinases) pathway. This ubiquitin-conjugating enzyme E2 N (UBE2N) inhibitor is considered as an important treatment option for neuroblastoma (NB) patients. NSC697923 prevents the multiplication and survival of diffuse large B-cell lymphoma (DLBCL) cells in vitro.

Application

NSC697923 has been used as an inhibitor in STING-dependent NF-κB (nuclear factor-κB) activation after DNA damage, mediated by TRAF6 (TNF receptor-associated factor 6).

Biochem/physiol Actions

NSC697923 is a cell-permeable and selective inhibitor of the ubiquitin-conjugating (E2) enzyme Ubc13-Uev1A that blocks the formation of the Ubc13 - ubiquitin thioester conjugate, and suppresses constitutive NF-kB activity in ABC-DLBCL cells. Also, NSC697923 inhibits the proliferation and survival of ABC-DLBCL and GCB-DLBCL cancer cells.
NSC697923 is a cell-permeable and selective inhibitor of the ubiquitin-conjugating (E2) enzyme Ubc13-Uev1A.

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This Item
662107N3415T8703
description

≥98% (HPLC)

description

The UbcH13 Inhibitor, NSC697923 controls the biological activity of UbcH13. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

description

≥98% (HPLC)

description

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

room temp

storage temp.

2-8°C

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 100 mg/mL

solubility

DMSO: ≥13 mg/mL

solubility

DMSO: >10 mg/mL, H2O: insoluble

color

white to beige

color

off-white

color

yellow to orange

color

white


Storage Class

11 - Combustible Solids

wgk

WGK 3



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