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SML0654

Entacapone

≥98% (HPLC), COMT inhibitor, powder

Synonym(s):

2-Cyano-N,N-diethyl-3-(3,4-dihydroxy-5-nitrophenyl)propenamide

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Size/SKUAvailabilityPrice
10 mg
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$85.30
50 mg
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$283.00

About This Item

Empirical Formula (Hill Notation):
C14H15N3O5
CAS Number:
Molecular Weight:
305.29
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$85.30


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Product Name

Entacapone, ≥98% (HPLC)

Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to light brown

solubility

DMSO: 20 mg/mL, clear

storage temp.

room temp

SMILES string

[N+](=O)([O-])c1c(c(cc(c1)\C=C(\C(=O)N(CC)CC)/C#N)O)O

InChI

1S/C14H15N3O5/c1-3-16(4-2)14(20)10(8-15)5-9-6-11(17(21)22)13(19)12(18)7-9/h5-7,18-19H,3-4H2,1-2H3/b10-5+

InChI key

JRURYQJSLYLRLN-BJMVGYQFSA-N

Application

Entacapone has been used in high-performance bioaffinity chromatography.

Biochem/physiol Actions

Entacapone is a catechol-O-methyl transferase (COMT) inhibitor. Used in treatment of Parkinson′s disease, entacapone is administered with L-DOPA to inihibit COMT from converting L-DOPA into a compound that cannot cross the blood brain barrier.
Entacapone is a catechol-O-methyl transferase (COMT) inhibitor. Antiparkinson; anti-Dyskinesia.
Entacapone acts predominantly in the intestine. It increases the bioavailability of levodopa. Levodopa is known to be associated with many complications such as motor fluctuations. COMT inhibitors have been used to overcome these adverse effects of levodopa by reducing its metabolism. Entacapone exhibits its inhibition action on COMT in the peripheral nervous system.

Features and Benefits

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item
Y0001249SML15031235933
description

≥98% (HPLC)

description

European Pharmacopoeia (EP) Reference Standard

description

≥98% (HPLC)

description

United States Pharmacopeia (USP) Reference Standard

assay

≥98% (HPLC)

assay

-

assay

≥98% (HPLC)

assay

-

form

powder

form

-

form

powder

form

-

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

-

storage temp.

room temp

storage temp.

2-8°C

storage temp.

room temp

storage temp.

-

solubility

DMSO: 20 mg/mL, clear

solubility

-

solubility

DMSO: 25 mg/mL, clear

solubility

-

color

white to light brown

color

-

color

white to beige

color

-


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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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