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SML0661

ML216

≥98% (HPLC)

Synonym(s):

1-(4-Fluoro-3-(trifluoromethyl)phenyl)-3-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)urea

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5 mg

Available to ship TODAYfromMILWAUKEE

$98.50
$83.72
25 mg

Available to ship TODAYfromMILWAUKEE

$397.00
$337.45

About This Item

Empirical Formula (Hill Notation):
C15H9F4N5OS
Molecular Weight:
383.32
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder

$83.72

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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

light orange to dark orange

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

Application

ML216 has been used in cell proliferation assays.

Biochem/physiol Actions

ML216 is a membrane permeable selective inhibitor of Bloom (BLM) helicase, a member of the RecQ DNA helicase family. Bloom′s syndrome, caused by a mutation in BLM, is associated with susceptibility to cancer, growth retardation, immunodeficiency, sunlight sensitivity, and fertility defects. ML216 is selective for BLM over other members of the RecQ family, especially in vivo, and appears to act at the BLM-nucleic acid substrate binding site, inhibiting DNA binding and blocking BLM′s helicase activity. ML216 could be useful in studies of tumor cells depending on the ALT (alternative lengthening of telomeres) mechanism for telomere maintenance rather than on telomerase, which are proposed to be susceptible to BLM inhibition.
ML216 is a membrane permeable selective inhibitor of Bloom (BLM) helicase.
ML216 is a 4-F-phenyl analog. It blocks cell proliferation of BLM-proficient fibroblast cells (PSNF5) and shows very less effects on BLM-deficient fibroblast cells (PSNG13).

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ML216 ≥98% (HPLC)

Sigma-Aldrich

SML0661

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NS3623 ≥98% (HPLC)

Sigma-Aldrich

SML2843

NS3623

A-1070722 ≥98% (HPLC)

Sigma-Aldrich

SML0863

A-1070722

YU142670 ≥98% (HPLC)

Sigma-Aldrich

SML1806

YU142670

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 15 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear (warmed)

color

light orange to dark orange

color

white to beige

color

white to beige

color

white to light brown

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H413

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 4

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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