Skip to Content
MilliporeSigma

Key Documents

View All Documentation

Skip To

SML0664

LM11A-31 dihydrochloride

≥95% (HPLC)

Synonym(s):

2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]-pentanamide dihydrochloride

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Pack SizeSKUAvailabilityPrice
5 mg
Check Cart for Availability
$73.20
25 mg
Check Cart for Availability
$284.00

About This Item

Empirical Formula (Hill Notation):
C12H25N3O2 · 2HCl
CAS Number:
1214672-15-7
Molecular Weight:
316.27
NACRES:
NA.77
PubChem Substance ID:
329825578
UNSPSC Code:
51111800
MDL number:
MFCD11505486
Assay:
≥95% (HPLC)
Form:
oil
Quality level:
100
Storage condition:
desiccated

$73.20

Check Cart for Availability
​
Request a Bulk Order
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Level

100

assay

≥95% (HPLC)

form

oil

storage condition

desiccated

color

colorless to yellow

storage temp.

2-8°C

SMILES string

Cl.Cl.CCC(C)C(N)C(=O)NCCN1CCOCC1

InChI

1S/C12H25N3O2.2ClH/c1-3-10(2)11(13)12(16)14-4-5-15-6-8-17-9-7-15;;/h10-11H,3-9,13H2,1-2H3,(H,14,16);2*1H

InChI key

LLIHJRRZJDEKLB-UHFFFAOYSA-N

Application

LM11A-31 dihydrochloride has been used to study the effect of p75 neurotrophin receptor (p75 NTR) blockade, by non-peptide LM11A-31 ligand, on PC12 cell viability.[1]

Biochem/physiol Actions

LM11A-31 is a non-peptide ligand of the p75 neurotrophin receptor (p75NTR). LM11A-31 blocks pro-NGF induced cell death in neuronal cultures, and protects neuronal cells from the the cytotoxic effects of cisplatin or methotrexate. Oral administration of LM11A-31 promotes the survival of oligodendrocytes and myelinated axons in a mouse spinal cord injury model and improves function in both weight-bearing and non-weight bearing tests.
LM11A-31 is a p75 neurotrophin receptor (p75NTR) ligand.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
SML2784SML2153S1697
LM11A-31 dihydrochloride ≥95% (HPLC)

Sigma-Aldrich

SML0664

LM11A-31 dihydrochloride

CMPD101 hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML2784

CMPD101 hydrochloride

TAM1 hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML2153

TAM1 hydrochloride

SPD304 ≥98% (HPLC), solid

Sigma-Aldrich

S1697

SPD304

form

oil

form

powder

form

powder

form

solid

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

desiccated

storage condition

desiccated

storage condition

-

storage condition

-

color

colorless to yellow

color

white to beige

color

white to beige

color

white

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000133995
0000133996
0000064467
0000023507
0000023508

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Different responses of PC12 cells to different pro-nerve growth factor protein variants
Soligo M, et al.
Neurochemistry International, 129, 104498-104498 (2019)
Marzia Soligo et al.
Neurochemistry international, 129, 104498-104498 (2019-07-07)
The present work aimed to explore the innovative hypothesis that different transcript/protein variants of a pro-neurotrophin may generate different biological outcomes in a cellular system. Nerve growth factor (NGF) is important in the development and progression of neurodegenerative and cancer
Valentina Pallottini et al.
Cells, 9(10) (2020-10-08)
Despite its undisputable role in the homeostatic regulation of the nervous system, the nerve growth factor (NGF) also governs the relevant cellular processes in other tissues and organs. In this study, we aimed at assessing the expression and the putative

Global Trade Item Number

SKUGTIN
SML0664-25MG04061833223468
SML0664-5MG04061833223475