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SML0684

SF1670

≥98% (HPLC)

Synonym(s):

N-(9,10-Dihydro-9,10-dioxo-2-phenanthrenyl)-2,2-dimethyl-propanamide, N-(9,10-Dioxo-9,10-dihydro-phenanthren-2-yl)-2,2-dimethylpropionamide

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Size/SKUAvailabilityPrice
5 mg
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$268.00

About This Item

Empirical Formula (Hill Notation):
C19H17NO3
CAS Number:
Molecular Weight:
307.34
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$268.00


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

, light pink to red to very dark purple

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

N(c1cc2c(cc1)c3c(cccc3)C(=O)C2=O)C(=O)C(C)(C)C

InChI

1S/C19H17NO3/c1-19(2,3)18(23)20-11-8-9-13-12-6-4-5-7-14(12)16(21)17(22)15(13)10-11/h4-10H,1-3H3,(H,20,23)

InChI key

VZQDDSYKVYARDW-UHFFFAOYSA-N

Application

SF1670 has been used:
  • To study the effect of microRNA-30a on PTEN (phosphatase and tensin homologue deleted on chromosome 10 ) expression regulation.
  • To study the formation of autophagosomes, induced by EGF (Epidermal growth factor) - dependent PTEN expression.
  • To study the role of PTEN in the regulation of autophagy induction in human normal endometrial stromal cells.

Biochem/physiol Actions

SF1670 is a selective PTEN (phosphatase and tensin homolog) inhibitor with an IC50 of 2 micromolar. PTEN inhibition by SF1670 was shown to increase neutrophil activity (polarization, phagocytosis, oxidative burst, and recruitment to site of infection), thereby enhancing the inflammatory response and bacteria-killing capacity of neutopenic mice.
SF1670 is a selective PTEN (phosphatase and tensin homolog) inhibitor.
PTEN prevents PI3-K(phosphoinositide 3-kinase)/Akt signaling pathway, which is very essential for neuronal regeneration. Therefore, inhibition of PTEN by SF1670 may support neuronal regeneration.

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This Item
SML2233SML2469M9651
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

>99% (HPLC), powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

>99% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

200

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

-

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear

solubility

H2O: 50 mg/mL

color

, light pink to red to very dark purple

color

white to beige

color

faint yellow to dark orange

color

white


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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