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SML0744

LDN-27219

≥98% (HPLC)

Synonym(s):

2-[(3,4-Dihydro-4-oxo-3,5-diphenylthieno[2,3-d]pyrimidin-2-yl)thio]-acetic acid hydrazide

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Pack SizeSKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$115.00
25 mg

Available to ship TODAYfromMILWAUKEE

$307.00

About This Item

Empirical Formula (Hill Notation):
C20H16N4O2S2
CAS Number:
Molecular Weight:
408.50
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$115.00


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 15 mg/mL, clear

storage temp.

−20°C

SMILES string

[s]1c2nc([n]([c](c2c(c1)c4ccccc4)=O)c3ccccc3)SCC(=O)NN

InChI

1S/C20H16N4O2S2/c21-23-16(25)12-28-20-22-18-17(15(11-27-18)13-7-3-1-4-8-13)19(26)24(20)14-9-5-2-6-10-14/h1-11H,12,21H2,(H,23,25)

InChI key

WLBUICQBNZXIDJ-UHFFFAOYSA-N

Biochem/physiol Actions

LDN-27219 is a revesible inhibitor of transglutaminase 2 (TG2) that binds to the GTP binidng site of the enzyme and inhbits activity with and IC50 of 600 nM.
LDN-27219 is a revesible inhibitor of transglutaminase 2 (TG2).
LDN-27219 is a thieno[2,3-d]pyrimidine-4-one-acylhydrazide derivative.[1] Closed conformation of TG2 induced by LDN-27219 can be a potential therapeutic strategy for age-related vascular dysfunction and lowering blood pressure.[2]

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This Item
SML2902SML0929SML2822
assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 15 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

white to beige

color

white to beige

color

white to light brown


pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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Global Trade Item Number

SKUGTIN
SML0744-5MG04061832982670
SML0744-25MG04061832982663

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