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SML0750

TPPU

≥98% (HPLC)

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Synonym(s):

1-Trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea, N-[1-(1-Oxopropyl)-4-piperidinyl]-N′-[4-(trifluoromethoxy)phenyl]-urea

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Size/SKUAvailabilityPrice
5 mg
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$141.00
25 mg
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$532.00

About This Item

Empirical Formula (Hill Notation):
C16H20F3N3O3
CAS Number:
Molecular Weight:
359.34
UNSPSC Code:
51111800
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$141.00

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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

FC(F)(F)Oc1ccc(cc1)NC(=O)NC2CCN(CC2)C(=O)CC

InChI

1S/C16H20F3N3O3/c1-2-14(23)22-9-7-12(8-10-22)21-15(24)20-11-3-5-13(6-4-11)25-16(17,18)19/h3-6,12H,2,7-10H2,1H3,(H2,20,21,24)

InChI key

AAJMQTLFRTZCJK-UHFFFAOYSA-N

Application

TPPU has been used as a soluble epoxide hydrolase (SEH) inhibitor to characterize its pharmacokinetic (PK) and pharmacodynamic properties in rodents. It has also been used as a SEH inhibitor to study its effects on 12,13-dihydroxy-9Z-octadecenoic acid (12,13-DiHOME) concentrations in nervous tissues.

Biochem/physiol Actions

TPPU is a potent sEH inhibitor (IC50 = 3.7 nM) that has been shown to have very favorable PK attributes in cynomolgus monkeys. sEH converts epoxyeicosatrienoic acids (EETs) to dihydroxyiecosatrienoic acids (DHETs), and sEH inhibitors display anti-inflammatory and anti-atherosclerotic effects.
TPPU is a potent sEH inhibitor.

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This Item
SML1355
description

≥98% (HPLC)

description

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 10 mg/mL, clear (warmed)

solubility

DMSO: 5 mg/mL, clear (warmed)

color

white to beige

color

yellow to orange


Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Codes

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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