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PreQ1 dihydrochloride

Name: PreQ1 dihydrochloride
Brand: SIGMA
Price: 129 USD
Availability: InStock

≥98% (HPLC), PreQ1 riboswitch regulator, powder

Synonym(s):

2-Amino-5-(aminomethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one dihydrochloride, 7-Aminomethyl-7-deazaguanine dihydrochloride, Pre-queuosine1 dihydrochloride

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Pack Size	SKU	Availability	Price
5 mg		Available to ship TODAYfromMILWAUKEE	$129.00
25 mg		Available to ship TODAYfromMILWAUKEE	$553.00 $470.05

About This Item

Empirical Formula (Hill Notation):

C₇H₉N₅O · 2HCl

CAS Number:

86694-45-3

Molecular Weight:

252.10

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated

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Properties

Product Name

PreQ1 dihydrochloride, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to light brown

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

Cl.Cl.[nH]1c2nc([nH][c](c2c(c1)CN)=O)N

InChI key

WUMBRQKOLVTYTB-UHFFFAOYSA-N

Description

Biochem/physiol Actions

PreQ1 (pre-queuosine1) is an intermediate of the queuosine pathway. Also, PreQ1 binds with high affinity to the aptamer of PreQ1 riboswitch, which attenuates protein expression.

PreQ1 (pre-queuosine1), an intermediate of the queuosine pathway, regulates the PreQ1 riboswitch.

PreQ1 is a nucleobase derived from guanine and a precursor of the modified base queuosine that is present in four tRNAs. Prequeuosine (preQ1) riboswitches are RNA regulatory elements present in the 5′ UTR of genes that participates in the biosynthesis and transport of preQ1.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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Show Differences

1 of 1

This Item	SML0588	C0742	SML1691
Sigma-Aldrich SML0807 PreQ1 dihydrochloride	Sigma-Aldrich SML0588 CP-94,253 dihydrochloride	Sigma-Aldrich C0742 CKI-7 dihydrochloride	Sigma-Aldrich SML1691 ZM323881 hydrochloride
form powder	form powder	form solid	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. room temp	storage temp. −20°C	storage temp. 2-8°C
storage condition desiccated	storage condition desiccated	storage condition desiccated	storage condition desiccated
solubility DMSO: 5 mg/mL, clear (warmed)	solubility H₂O: 15 mg/mL, clear	solubility H₂O: >5 mg/mL	solubility DMSO: 10 mg/mL, clear

pictograms

GHS07

signalword

Warning

hcodes

H302,H315,H319,H335

pcodes

P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

0000296339

0000237260

0000205603

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Articles

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Discovery of novel bacterial queuine salvage enzymes and pathways in human pathogens.

Yifeng Yuan et al.

Proceedings of the National Academy of Sciences of the United States of America, 116(38), 19126-19135 (2019-09-05)

Queuosine (Q) is a complex tRNA modification widespread in eukaryotes and bacteria that contributes to the efficiency and accuracy of protein synthesis. Eukaryotes are not capable of Q synthesis and rely on salvage of the queuine base (q) as a

Structural determinants for ligand capture by a class II preQ1 riboswitch

Kang M, et al.

Proceedings of the National Academy of Sciences of the USA, 111(6), E663-E671 (2014)

Hierarchical Conformational Dynamics Confers Thermal Adaptability to preQ1 RNA Riboswitches.

Zhou Gong et al.

Journal of molecular biology, 432(16), 4523-4543 (2020-06-12)

Single-stranded noncoding regulatory RNAs, as exemplified by bacterial riboswitches, are highly dynamic. The conformational dynamics allow the riboswitch to reach maximum switching efficiency under appropriate conditions. Here we characterize the conformational dynamics of preQ1 riboswitches from mesophilic and thermophilic bacterial

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Global Trade Item Number

SKU	GTIN
SML0807-5MG	04061833223932
SML0807-25MG	04061833223925

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