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SML0814

ESI-09

≥98% (HPLC)

Synonym(s):

α-[2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-b-oxo-3-isoxazolepropanenitrile

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$167.00
25 mg

Available to ship TODAYfromMILWAUKEE

$665.00

About This Item

Empirical Formula (Hill Notation):
C16H15ClN4O2
CAS Number:
Molecular Weight:
330.77
UNSPSC Code:
41106305
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$167.00


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

, faint yellow to dark orange

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

Clc1cc(ccc1)N\N=C(\C(=O)c2n[o]c(c2)C(C)(C)C)/C#N

InChI

1S/C16H15ClN4O2/c1-16(2,3)14-8-12(21-23-14)15(22)13(9-18)20-19-11-6-4-5-10(17)7-11/h4-8,19H,1-3H3/b20-13+

InChI key

DXEATJQGQHDURZ-DEDYPNTBSA-N

Application

ESI-09 has been used as an antagonist for exchange factor directly activated by cAMP (EPAC).

Biochem/physiol Actions

ESI-09 is a potent, specific inhibitor of EPAC (exchange protein directly activated by cAMP).
ESI-09 is a potent, specific inhibitor of EPAC (exchange protein directly activated by cAMP). ESI-09 inhibits EPAC1 and EPAC2 with IC50 values of 3.2 and 1.4 μM, respectively, with no activity against PKA at 25 μM. In pancreatic cell lines, the compound blocks phosphorylation of Akt and insulin secretion. ESI-09 inhibits migration of pancreatic cancer cell lines.

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This Item
SML2465SML0345SML0917
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: ≥5 mg/mL

solubility

DMSO: 20 mg/mL, clear

color

, faint yellow to dark orange

color

faint yellow to dark orange

color

white to beige

color

white to beige


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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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