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SML0857

HQL 79

≥98% (HPLC)

Synonym(s):

4-Benzhydryloxy-1-[3-(1H-tetrazol-5-yl)-propyl]-piperidine

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Size/SKUAvailabilityPrice
5 mg
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$77.70
$66.04

About This Item

Empirical Formula (Hill Notation):
C22H27N5O
CAS Number:
Molecular Weight:
377.48
UNSPSC Code:
41106300
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$66.04

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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

room temp

SMILES string

[nH]1nnnc1CCCN2CCC(CC2)OC(c4ccccc4)c3ccccc3

InChI

1S/C22H27N5O/c1-3-8-18(9-4-1)22(19-10-5-2-6-11-19)28-20-13-16-27(17-14-20)15-7-12-21-23-25-26-24-21/h1-6,8-11,20,22H,7,12-17H2,(H,23,24,25,26)

InChI key

TZQGXAHOROZEKN-UHFFFAOYSA-N

Biochem/physiol Actions

HQL-79 is a selective inhibtor of hematopoietic prostaglandin D (PGD) synthase, one of two synthases involved in the production of Prostaglandin D2 (PGD2) from arachidonic acid. PGD2 is a lipid signaling molecule, which activates two receptors, DP1 involved in centrally mediated processes such as sleep and pain and DP2 involved and inflammation. The two PGD synthases involved in its synthesis are lipocalin-type (L-PGDS) and hematopoietic (H-PDGS), which acts to form PGD2 in mast cells, Th2 cells, microglia, and other inflammatory cells/tissues. HQL-79 selectively inhibited the activity of recombinant H-PGDS with an IC50 of 6 μM and had almost no effect on COX-1, COX-2, m-PGES, or L-PGDS up to 300 μM. HQL-79 has anti-inflammatory activity in vitro and in vivo.
HQL-79 is a selective inhibtor of hematopoietic prostaglandin D (PGD) synthase.
HQL 79 is an orally active anti-allergic agent that acts as an antagonist for histamine H1 receptors (H1R), eliciting anti-asthmatic effects. It interacts with prostaglandin (PG) D synthase (H-PGDS) in the catalytic region. It may be potential lead due to its H-PGDS inhibition to treat allergies.

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This Item
J3770PZ0242PZ0233
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

solid

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

DMSO: >20 mg/mL, H2O: insoluble

solubility

DMSO: 20 mg/mL, clear

solubility

H2O: 10 mg/mL, clear

color

white to beige

color

white to off-white

color

white to beige

color

white to light brown


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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