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SML0929

HS38

≥95% (HPLC)

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Synonym(s):

2-[[1-(3-Chlorophenyl)-4,5-dihydro-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio]-propanamide, 2-[[1-(3-Chlorophenyl)-4-oxo-5H-pyrazolo[5,4-d]pyrimidin-6-yl]sulfanyl]propanamide

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Size/SKUAvailabilityPrice
10 mg
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$83.20

About This Item

Empirical Formula (Hill Notation):
C14H12ClN5O2S
CAS Number:
Molecular Weight:
349.80
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
powder

$83.20

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Quality Segment

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

Biochem/physiol Actions

HS38 is a potent and selective ATP-competitive inhibitor of Death-associated protein kinases DAPK1 (IC50 = 200 nM, 89% inhibition at 10 RM) and ZIPK (Zipper-interacting protein kinase, also called DAPK3) that regulate programmed cell death, and also inhibits the closely related PIM3 kinase (IC50 = 200 nM, 76% inhibition at 10 RM). In addition to mediating apoptosis, DAPK1 and ZIPK regulate both non-muscle and smooth muscle myosin phosphorylation. HS38 specifically targeted ZIPK in smooth muscle, and decreased contractile force generated in mouse aorta, rabbit ileum, and calyculin A stimulated arterial muscle.
HS38 is a potent and selective ATP-competitive inhibitor that also targets the closely related PIM3 kinase.

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This Item
HPA028569HPA064809
description

≥95% (HPLC)

description

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

description

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody

form

powder

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

assay

≥95% (HPLC)

assay

-

assay

-

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

-

solubility

-

color

white to beige

color

-

color

-


Pictograms

Exclamation mark

Signal Word

Warning

Hazard Codes

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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