SML0959

Bis-1,4-(4-methoxybenzenesulfonamidyl)naphthalene

Name: Bis-1,4-(4-methoxybenzenesulfonamidyl)naphthalene
Brand: SIGMA
Price: 120 EUR

≥98% (HPLC)

Synonym(s):

Compound 16, N,N′-(Naphthalene-1,4-diyl)bis(4-methoxybenzenesulfonamide)

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5 MG

€120.00

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₂₂N₂O₆S₂

CAS Number:

321694-20-6

Molecular Weight:

498.57

NACRES:

NA.77

UNSPSC Code:

12352200

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Key Documents

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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

, white to light yellow to light gray

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

Related Categories

Bioactive Small Molecule Inhibitors

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This Item	SML1922	SML1152	SML1949
Sigma-Aldrich SML0959 Bis-1,4-(4-methoxybenzenesulfonamidyl)naphthalene	Sigma-Aldrich SML1922 K67	Sigma-Aldrich SML1152 GSK137647A	Sigma-Aldrich SML1949 Synta66
form powder	form powder	form powder	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: 20 mg/mL, clear	solubility DMSO: 10 mg/mL, clear	solubility DMSO: 20 mg/mL, clear	solubility DMSO: 20 mg/mL, clear
color , white to light yellow to light gray	color white to beige	color white to beige	color white to beige

Biochem/physiol Actions

Bis-1,4-(4-methoxybenzenesulfonamidyl)naphthalene is a non-covalent inhibitor of the interaction between Kelch-like ECH-associated protein 1 (Keap1) and nuclear factor erythroid 2-related factor 2 (Nrf2). The Keap1–Nrf2 protein–protein interaction is considered a critical point of the Keap1–Nrf2–ARE (antioxidant response elements) system that protects cells from oxidative stress. Bis-1,4-(4-methoxybenzenesulfonamidyl)naphthalene prevents Keap1 repression of Nrf2 activation, allowing Nrf2 to initiate antioxidant response element (ARE) to protect the cell. Bis-1,4-(4-methoxybenzenesulfonamidyl)naphthalene has an IC₅₀of 2.7 micromolar and specifically binds to the Keap1 Kelch-DC domain.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

wgk

WGK 3

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Identification of a potent Nrf2 displacement activator among aspirin-containing prodrugs.

Irina N Gaisina et al.

Neurochemistry international, 149, 105148-105148 (2021-07-31)

Aspirin is a desired leaving group in prodrugs aimed at treatment of neurodegeneration and other conditions. A library of aspirin derivatives of various scaffolds potentially activating Nrf2 has been tested in Neh2-luc reporter assay which screens for direct Nrf2 protein

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Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Global Trade Item Number

SKU	GTIN
SML0959-5MG	04061832825090
SML0959-25MG	04061832825083

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Bis-1,4-(4-methoxybenzenesulfonamidyl)naphthalene