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SML0990

JW651

≥98% (HPLC)

Synonym(s):

1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(bis(4-chlorophenyl)methyl)piperazine-1-carboxylate

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Size/SKUAvailabilityPrice
5 mg

Estimated to ship TODAYfromMILWAUKEE

$129.00
$109.65

About This Item

Empirical Formula (Hill Notation):
C21H18Cl2F6N2O2
CAS Number:
Molecular Weight:
515.28
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$109.65

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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

ClC1=CC=C(C(C2=CC=C(Cl)C=C2)N3CCN(C(OC(C(F)(F)F)C(F)(F)F)=O)CC3)C=C1

InChI

1S/C21H18Cl2F6N2O2/c22-15-5-1-13(2-6-15)17(14-3-7-16(23)8-4-14)30-9-11-31(12-10-30)19(32)33-18(20(24,25)26)21(27,28)29/h1-8,17-18H,9-12H2

InChI key

UPIHQFKOCOKGEO-UHFFFAOYSA-N

Biochem/physiol Actions

JW651 is a potent selective inhibitor of MAGL, the enzyme predominantly responsible for the degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG). JW651 inhibited mouse MAGL with an IC50 ~38 nM compared to 10,380 for ABHD6, a serine hydrolase that acts as an alternative hydrolase of 2-AG and >100,000 for FAAH, the hydrolase that degrades the endocannabinoid anandamide (AEA). JW651 was used as the MAGL inhibitor along with JW912, a fluorescent inihibitor of both MAGL and ABHD6.
JW651 is a potent selective inhibitor of MAGL; active in vivo.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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This Item
SML1816SML1276SML1170
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 5 mg/mL, clear (warmed)

color

white to beige

color

white to beige

color

white to beige

color

white to beige


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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