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SML1009

PFK15

≥98% (HPLC)

Synonym(s):

1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$131.00
25 mg

Available to ship TODAYfromMILWAUKEE

$525.00
$446.25

About This Item

Empirical Formula (Hill Notation):
C17H12N2O
CAS Number:
Molecular Weight:
260.29
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$131.00


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

n1ccc(cc1)C(=O)\C=C\c2nc3c(cc2)cccc3

InChI

1S/C17H12N2O/c20-17(14-9-11-18-12-10-14)8-7-15-6-5-13-3-1-2-4-16(13)19-15/h1-12H/b8-7+

InChI key

UJJUKZPBUMCSJZ-BQYQJAHWSA-N

Application

PFK15, a PFKFB3 inhibitor has been used to investigate its effects on the modulation of autophagy and proliferation in rhabdomyosarcoma (RD) cells.

Biochem/physiol Actions

PFK15 is potent and selective antagonist of PFKB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3) that causes a rapid induction of apoptosis in cancer and transformed cells. PFK15 inhibits the growth of LLC xenografts.
PFK15 is potent and selective antagonist of PFKB3.
PFK15 is also referred as 1-(4-pyridinyl)-3-(2-quinolinyl)-2-propen-1-one. It prevents autophagy and multiplication in rhabdomyosarcoma cells. PFK15 results in cell death in gastric cancer cells via mitochondrial pathway. It also blocks MKN45 (human gastric cancer cell lines) tumor growth in vivo. PFK15 promotes cell cycle arrest and changes the upregulation of key cell cycle proteins.

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This Item
SML0939SML3145SML0666
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

DMSO: 20 mg/mL, clear

color

white to beige

color

yellow to orange

color

white to beige

color

white to beige


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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