A working solution in dimethylsulfoxide (DMSO) can be stored at ?20°C.
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SML1068
TIC10 angular
≥98% (HPLC)
Synonym(s):
7-Benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4H)-one., ONC-201, ONC201, TIC10 corrected
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Check Cart for Availability | $154.00 |
25 mg | Check Cart for Availability | $620.00 |
About This Item
Empirical Formula (Hill Notation):
C24H26N4O
Molecular Weight:
386.49
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear
storage temp.
2-8°C
General description
TIC10 (TRAIL-inducing compound 10) is an anticancer molecule also referred as ONC201.
Biochem/physiol Actions
TIC10 angular is a potent blood brain barrier penetrant and orally active inducer of TRAIL production that induces death of multiple human cancers.
TIC10 angular is a potent blood brain barrier penetrant and orally active inducer of TRAIL production that induces death of multiple human cancers. TIC10 angular inactivates both Akt and ERK, which results in Foxo3a nuclear factor migration to the nucleus and binding to TRAIL promoter.
Features and Benefits
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description ≥95% (HPLC) | description ≥98% (HPLC) | description ≥98% (HPLC) |
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥95% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 5 mg/mL, clear | solubility DMSO: 3 mg/mL, clear (warmed) | solubility DMSO: ≥7 mg/mL | solubility DMSO: 2 mg/mL, clear |
| color white to beige | color white to beige | color white to tan | color white to beige |
signalword
Warning
hcodes
pcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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How long can I store a working solution in dimethylsulfoxide (DMSO) at −20°C?
1 answer-
Helpful?
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What is storage temperature for 100 mM TIC10 in DMSO? 4 degrees or -20 degree?
1 answer-
A working solution in dimethylsulfoxide (DMSO) can be stored at −20°C.
Helpful?
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