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SML1116

PQ-10

≥98% (HPLC)

Synonym(s):

6,7-Dimethoxy-4-[(3R)-3-(2-quinoxalinyloxy)-1-pyrrolidinyl]-quinazoline, PQ 10

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Size/SKUAvailabilityPrice
25 mg

Estimated to ship onOctober 01, 2026fromMILWAUKEE

$356.00

About This Item

Empirical Formula (Hill Notation):
C22H21N5O3
CAS Number:
Molecular Weight:
403.43
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$356.00


Estimated to ship onOctober 01, 2026Details


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

COC1=CC2=C(N3C[C@H](OC4=CN=C(C=CC=C5)C5=N4)CC3)N=CN=C2C=C1OC

InChI

1S/C22H21N5O3/c1-28-19-9-15-18(10-20(19)29-2)24-13-25-22(15)27-8-7-14(12-27)30-21-11-23-16-5-3-4-6-17(16)26-21/h3-6,9-11,13-14H,7-8,12H2,1-2H3/t14-/m1/s1

InChI key

UBIIFKJMNRPNMT-CQSZACIVSA-N

Biochem/physiol Actions

PQ-10 is a potent and selective inhibitor of phosphodiesterase 10A (PDE10).
PQ-10 is a potent and selective inhibitor of phosphodiesterase 10A (PDE10). Apparently, PQ-10 enhances basic auditory information processing in rats. PQ-10 as other PED10 inhibitors suppresses a growth of human non-small cell lung cancer (NSCLC) cell lines.
PQ-10 (6,7-dimethoxy-4-[3-(quinoxalin-2-yloxy)pyrrolidin-1-yl]quinazoline), is capable of suppressing tumor cell growth. It can also reverse the RO-4-1284-induced sedation and catalepsy.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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This Item
SML0229SML1037PZ0171
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

>98% (HPLC)

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

>98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: ≥10 mg/mL at warmed to 60 °C

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: >5 mg/mL

color

white to beige

color

white to beige

color

white to beige

color

white to off-white


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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