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SML1218

Pheophorbide-a

≥90% (HPLC)

Synonym(s):

pheophorbide a, (3S,4S,21R)-9-Ethenyl-14-ethyl-21-(methoxycarbonyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbinepropanoic acid, Deacetyl-2-vinylbacteriopheophorbide, Pheophorbide a5

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Size/SKUAvailabilityPrice
10 mg
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$52.30

About This Item

Empirical Formula (Hill Notation):
C35H36N4O5
CAS Number:
Molecular Weight:
592.68
UNSPSC Code:
12161501
PubChem Substance ID:
MDL number:
Assay:
≥90% (HPLC)
Form:
powder
Storage condition:
protect from light

$52.30


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assay

≥90% (HPLC)

form

powder

storage condition

protect from light

color

blue, to dark brown to black

solubility

DMSO: 0.5 mg/mL, clear (warmed)

storage temp.

−20°C

SMILES string

O=C([C@@H]1C(OC)=O)C(C(N/2)=C1C([C@@H](CCC(O)=O)[C@@H]/3C)=NC3=C/4)=C(C)C2=C\C5=N/C(C(C)=C5CC)=C\C6=C(C=C)C(C)=C4N6

InChI

1S/C35H36N4O5/c1-8-19-15(3)22-12-24-17(5)21(10-11-28(40)41)32(38-24)30-31(35(43)44-7)34(42)29-18(6)25(39-33(29)30)14-27-20(9-2)16(4)23(37-27)13-26(19)36-22/h8,12-14,17,21,31,36,39H,1,9-11H2,2-7H3,(H,40,41)/b22-12-,23-13-,24-12-,25-14-,26-13-,27-14-,32-30-/t17-,21-,31+/m0/s1

InChI key

NSFSLUUZQIAOOX-QEWKCGBTSA-N

Application

Pheophorbide-a has been used as a photosensitizer:
  • for the photodynamic therapy (PDT) in oral cancer cell lines
  • to test its effect on inducing oxidative stress and death in L. amazonensis
  • to test its effect on the viability of HeLa cells

Biochem/physiol Actions

Pheophorbide-a, due to its photosensitizing effect, may serve as a promising bioactive compound to treat leishmaniasis. It is a metabolite of chlorophyll and possesses immunostimulation functionality. Pheophorbide-a is a photosensitizer for the photodynamic therapy. It is an ATP Binding Cassette Subfamily G Member 2 (ABCG2) transporter specific substrate. Overexpression of ATP-binding cassette (ABC) transporters in cancer cells is associated with the multidrug resistance phenotype.

Other Notes

light sensitive

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This Item
SML0527PZ0327SML2301
description

≥90% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥97% (HPLC)

form

powder

form

powder

form

powder

form

powder

assay

≥90% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥97% (HPLC)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

room temp

storage temp.

2-8°C

solubility

DMSO: 0.5 mg/mL, clear (warmed)

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

storage condition

protect from light

storage condition

protect from light

storage condition

-

storage condition

-

color

blue, to dark brown to black

color

yellow to orange

color

white to beige

color

white to beige


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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