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SML1222

Lopinavir

≥98% (HPLC)

Synonym(s):

(αS)-N-[(1S,3S,4S)-4-[[(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2-oxo-1(2H)-

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Size/SKUAvailabilityPrice
10 mg

Available to ship TODAYfromMILWAUKEE

$34.00
50 mg

Available to ship TODAYfromMILWAUKEE

$81.70

About This Item

Empirical Formula (Hill Notation):
C37H48N4O5
CAS Number:
Molecular Weight:
628.80
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$34.00


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Quality Segment

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -20 to -27°, c = 0.4 in methanol

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

SMILES string

N4(CCCNC4=O)[C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@@H](NC(=O)COc3c(cccc3C)C)Cc2ccccc2)Cc1ccccc1

InChI

1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/s1

InChI key

KJHKTHWMRKYKJE-SUGCFTRWSA-N

Application

Lopinavir has been used as a ZMPSTE24 and human immunodeficiency virus protease inhibitor.

Biochem/physiol Actions

Lopinavir is an antiviral HIV Protease Inhibitor. Lopinavir has insufficient bioavailability alone, so it is used in therapy in combination with Ritonavir, a HIV protease inhibitor, which inhibits cytochrome P450-3A4 (CYP3A4), a liver enzyme that normally metabolizes protease inhibitors. Lopinavir also has an ability to inhibit ZMPSTE24 (zinc metallopeptidase STE24).

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This Item
1370101PHR1927Y0001498
description

≥98% (HPLC)

description

United States Pharmacopeia (USP) Reference Standard

description

Pharmaceutical Secondary Standard; Certified Reference Material

description

European Pharmacopoeia (EP) Reference Standard

assay

≥98% (HPLC)

assay

-

assay

-

assay

-

form

powder

form

powder

form

powder

form

-

Quality Level

100

Quality Level

-

Quality Level

300

Quality Level

-

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 20 mg/mL, clear

solubility

methylene chloride: freely soluble, water: practically insoluble, chloroform: soluble, isopropanol: soluble, methanol: freely soluble

solubility

chloroform: soluble, isopropanol: soluble, methylene chloride: freely soluble, water: practically insoluble, methanol: freely soluble

solubility

-

color

white to beige

color

white to off-white

color

white to off-white

color

-


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Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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