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SML1243

Pyr10

≥98% (HPLC)

Synonym(s):

N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-benzenesulfonamide

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Size/SKUAvailabilityPrice
5 mg
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$129.00
25 mg
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$347.00

About This Item

Empirical Formula (Hill Notation):
C18H13F6N3O2S
CAS Number:
Molecular Weight:
449.37
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$129.00


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

FC(F)(F)c1[n](nc(c1)C(F)(F)F)c2ccc(cc2)N[S](=O)(=O)c3ccc(cc3)C

InChI key

CVALMMCIOLXHDM-UHFFFAOYSA-N

Biochem/physiol Actions

Pyr10 is a novel, selective inhibitor of the transient receptor potential channel TRPC3.
Pyr10 is a novel, selective inhibitor of the transient receptor potential channel TRPC3. Pyr10 blocks carbachol-induced calcium entry into TRPC3-transfected HEK293 cells (IC50 = 0.72 μM), with significantly lower activity against STIM1/Orai1 mediated release of calcium from endoplasmic reticulum (store operated calcium entry) in BRL-2H3 cells (IC50 = 13.08 μM).

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This Item
648494P0032SML1355
description

≥98% (HPLC)

description

-

description

≥98% (HPLC)

description

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

solid, semisolid

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 100 mg/mL

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 5 mg/mL, clear (warmed)

color

white to beige

color

orange-brown, white to off-white

color

white to beige

color

yellow to orange


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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