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SML1315

Ranirestat

≥97% (HPLC)

Synonym(s):

(3R)-2′-[(4-Bromo-2-fluorophenyl)methyl]-spiro[pyrrolidine-3,4′(1′H)-pyrrolo[1,2-a]pyrazine]-1′,2,3′,5(2′H)-tetrone., AS-3201

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Size/SKUAvailabilityPrice
5 mg
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$218.00

About This Item

Empirical Formula (Hill Notation):
C17H11BrFN3O4
CAS Number:
Molecular Weight:
420.19
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥97% (HPLC)
Form:
powder

$218.00


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Quality Segment

assay

≥97% (HPLC)

form

powder

optical activity

[α]/D -5 to -10°, c = 1.0 in methanol

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

SMILES string

O=C(N1CC2=C(F)C=C(Br)C=C2)C3=CC=CN3[C@@]4(CC(NC4=O)=O)C1=O

InChI

1S/C17H11BrFN3O4/c18-10-4-3-9(11(19)6-10)8-21-14(24)12-2-1-5-22(12)17(16(21)26)7-13(23)20-15(17)25/h1-6H,7-8H2,(H,20,23,25)/t17-/m1/s1

InChI key

QCVNMNYRNIMDKV-QGZVFWFLSA-N

Biochem/physiol Actions

Ranirestat (AS-3201) is an aldose reductase (AR) inhibitor.
Ranirestat (AS-3201) is an aldose reductase (AR) inhibitor. Aldose reductase is a rate-limiting enzyme in the conversion of D-glucose to fructose via D-sorbitol. Ranirestat has been implicated in diabetic complications (cataract formation, retinopathy, neuropathy, nephropathy). Ranirestat prevents sorbitol accumulation and is thus hoped to be effective in the remedy of diabetic neuropathy.

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This Item
T89491643437SML0688
description

≥97% (HPLC)

description

≥98% (HPLC), solid

description

United States Pharmacopeia (USP) Reference Standard

description

≥98% (HPLC)

form

powder

form

solid

form

-

form

powder

assay

≥97% (HPLC)

assay

≥98% (HPLC)

assay

-

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

100

storage temp.

−20°C

storage temp.

-

storage temp.

-

storage temp.

2-8°C

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: >5 mg/mL at 60 °C, H2O: insoluble

solubility

-

solubility

DMSO: 1 mg/mL, clear (warmed)

color

white to beige

color

white

color

-

color

faintly pink to red


pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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