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SML1347

Alvimopan

≥98% (HPLC)

Synonym(s):

ADL-8-2698, LY-246736, N-[(2S)-2-[[(3R,4R)-4-(3-Hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]glycine

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$129.00
$134.00
25 mg

Available to ship TODAYfromMILWAUKEE

$509.00

About This Item

Empirical Formula (Hill Notation):
C25H32N2O4
CAS Number:
Molecular Weight:
424.53
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$134.00

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Quality Segment

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D +46 to +52°, c = 1.0 in DMSO

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

C[C@H]1CN(C[C@@H](C(NCC(O)=O)=O)CC2=CC=CC=C2)CC[C@]1(C3=CC=CC(O)=C3)C

InChI

1S/C25H32N2O4/c1-18-16-27(12-11-25(18,2)21-9-6-10-22(28)14-21)17-20(24(31)26-15-23(29)30)13-19-7-4-3-5-8-19/h3-10,14,18,20,28H,11-13,15-17H2,1-2H3,(H,26,31)(H,29,30)/t18-,20-,25+/m0/s1

InChI key

UPNUIXSCZBYVBB-JVFUWBCBSA-N

Gene Information

human ... OPRM1(4988)

Biochem/physiol Actions

Alvimopan is a gastroprokinetic peripheral mu-opioid receptor antagonist.
Alvimopan is a gastroprokinetic peripheral mu-opioid receptor antagonist. As a drug, Alvimopan is given to patients undergoing bowel surgery to protect the bowel from the effects of opioid medications that are used to treat pain, blocking the undesirable GI side-effects of the opioid agonists without affecting analgesia or causing withdrawal. Alvimopan does not cross the blood-brain barrier, competitively binding to gastrointestinal tract mu-opioid receptors.

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This Item
SMB00055Y000155968120
description

≥98% (HPLC)

description

≥95% (LC/MS-ELSD)

description

European Pharmacopoeia (EP) Reference Standard

description

≥95.0% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (LC/MS-ELSD)

assay

-

assay

≥95.0% (HPLC)

form

powder

form

solid

form

-

form

-

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

solubility

DMSO: 10 mg/mL, clear

solubility

-

solubility

-

solubility

-

color

white to beige

color

-

color

-

color

-


Pictograms

Exclamation markEnvironment

Signal Word

Warning

Hazard Codes

Hazard Classifications

Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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