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SML1352

CINK4

≥95% (HPLC)

Synonym(s):

trans-4-[[6-(Ethylamino)-2-[[1-(phenylmethyl)-1H-indol-5-yl]amino]-4-pyrimidinyl]amino]-cyclohexanol

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Size/SKUAvailabilityPrice
25 mg

Estimated to ship TODAYfromMILWAUKEE

$346.00

About This Item

Empirical Formula (Hill Notation):
C27H32N6O
CAS Number:
Molecular Weight:
456.58
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
powder

$346.00


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Quality Segment

assay

≥95% (HPLC)

form

powder

color

white to light brown

solubility

DMSO: 25 mg/mL, clear

storage temp.

2-8°C

SMILES string

O[C@@H]1CC[C@@H](NC2=CC(NCC)=NC(NC3=CC=C(N(CC4=CC=CC=C4)C=C5)C5=C3)=N2)CC1

InChI

1S/C27H32N6O/c1-2-28-25-17-26(29-21-8-11-23(34)12-9-21)32-27(31-25)30-22-10-13-24-20(16-22)14-15-33(24)18-19-6-4-3-5-7-19/h3-7,10,13-17,21,23,34H,2,8-9,11-12,18H2,1H3,(H3,28,29,30,31,32)/t21-,23-

InChI key

YVXCDLCJCIDFHE-AFARHQOCSA-N

Biochem/physiol Actions

CINK4 is a specific inhbitor of CDK4/cyclin D1 complexes (IC50 = 1.5 mM). CINK4 has greater than 50 fold selectivity over CDK1 or CDK2. CINK4 dose-dependently inhibits phosphorylation of retinoblastoma (Rb) and induces G0-G1 cell cycle arrest and apoptosis in cancer cell lines.
CINK4 is a specific inhbitor of CDK4/cyclin D1 complexes.

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This Item
HPA007286793663900695
description

≥95% (HPLC)

description

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

description

for inkjet printing, with ethyl cellulose in cyclohexanone and terpineol, inkjet printable

description

for inkjet printing, photonically annealable

assay

≥95% (HPLC)

assay

-

assay

-

assay

-

form

powder

form

buffered aqueous glycerol solution

form

liquid

form

liquid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

-

storage temp.

-

solubility

DMSO: 25 mg/mL, clear

solubility

-

solubility

-

solubility

-

color

white to light brown

color

-

color

-

color

-


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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