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SML1372

Nifetepimine

≥95% (HPLC)

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Synonym(s):

1,2,3,4-Tetrahydro-6-methyl-4-(3-nitrophenyl)-2-oxo-5-pyrimidinecarboxylic acid ethyl ester, 5-Ethoxycarbonyl-6-methyl-4-(3-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-one, 6-Methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester, Ethyl-4-(3-nitrophenyl)-6-methyl-2-oxo-1,2,3,4 tetrahydropyrimidine-5 carboxylate

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Size/SKUAvailabilityPrice
25 mg

Available to ship TODAYfromMILWAUKEE

$292.00

About This Item

Empirical Formula (Hill Notation):
C14H15N3O5
CAS Number:
110448-29-8
Molecular Weight:
305.29
NACRES:
NA.77
PubChem Substance ID:
329825824
UNSPSC Code:
12352202
MDL number:
MFCD00128568
Assay:
≥95% (HPLC)
Form:
powder

$292.00

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Quality Segment

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(OCC)C1=C(C)NC(NC1C2=CC([N+]([O-])=O)=CC=C2)=O

InChI

1S/C14H15N3O5/c1-3-22-13(18)11-8(2)15-14(19)16-12(11)9-5-4-6-10(7-9)17(20)21/h4-7,12H,3H2,1-2H3,(H2,15,16,19)

InChI key

PPBNQKLDXXHPMH-UHFFFAOYSA-N

Biochem/physiol Actions

Nifetepimine is a dihydropyrimidone calcium channel blocker that down-modulates SERCA3 (sarco/endoplasmic reticulum Ca2+ -ATPase 3) pump, and protects of the CD4+ T cells from tumor-induced apoptosis. Nifetepimine induces apoptotic cell death in triple negative breast cancer (TNBC) cells by stimulation of cross-talk between ER stress and the MEK/ERK pathway.
Nifetepimine is a dihydropyrimidone calcium channel blocker.

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This Item
481981PHR1290SMB00074
Nifetepimine ≥95% (HPLC)

Sigma-Aldrich

SML1372

Nifetepimine

Nifedipine Relatively selective blocker of L-type Ca2+ channels.

Sigma-Aldrich

481981

Nifedipine

Nifedipine Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1290

Nifedipine

Viniferin ≥95% (LC/MS-ELSD)

Sigma-Aldrich

SMB00074

Viniferin

description

≥95% (HPLC)

description

Relatively selective blocker of L-type Ca2+ channels.

description

Pharmaceutical Secondary Standard; Certified Reference Material

description

≥95% (LC/MS-ELSD)

assay

≥95% (HPLC)

assay

≥98% (UV)

assay

-

assay

≥95% (LC/MS-ELSD)

form

powder

form

solid

form

-

form

solid

Quality Level

100

Quality Level

100

Quality Level

300

Quality Level

200

storage temp.

2-8°C

storage temp.

10-30°C

storage temp.

2-30°C

storage temp.

−20°C

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: soluble, ethanol: soluble

solubility

-

solubility

-

color

white to beige

color

yellow

color

-

color

-

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Codes

H302,H319

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
085M4716V

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