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SML1377

R-7050

≥95% (HPLC)

Synonym(s):

8-Chloro-4-(phenylsulfanyl)-1-(trifluoromethyl)[1,2,4]triazolo[4,3-a]quinoxaline, 8-Chloro-4-(phenylthio)-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline

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Size/SKUAvailabilityPrice
5 mg
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$107.00

About This Item

Empirical Formula (Hill Notation):
C16H8ClF3N4S
CAS Number:
Molecular Weight:
380.77
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Assay:
≥95% (HPLC)
Form:
powder

$107.00


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Quality Segment

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

shipped in

wet ice

storage temp.

−20°C

SMILES string

ClC1=CC=C(N=C(SC2=CC=CC=C2)C3=NN=C(C(F)(F)F)N34)C4=C1

InChI

1S/C16H8ClF3N4S/c17-9-6-7-11-12(8-9)24-13(22-23-15(24)16(18,19)20)14(21-11)25-10-4-2-1-3-5-10/h1-8H

InChI key

SUUMKHOVGVYGOP-UHFFFAOYSA-N

Biochem/physiol Actions

R-7050 is a cell-permeable TNF-α receptor antagonist that blocks TNF-α-induced binding of TNF-αRI with TNFαR-associated death domain protein and receptor interacting protein 1, blocking internalization of the TNFα-TNFαR complex. R-7050 was found to reduce neurovascular injury in a mouse model of hemorrhagic stroke.
R-7050 is a cell-permeable TNF-α receptor antagonist.

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This Item
654257SML0639SML1806
description

≥95% (HPLC)

description

The TNF-α Antagonist III, R-7050, also referenced under CAS 303997-35-5, controls the biological activity of TNF-α.

description

≥98% (HPLC)

description

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

assay

≥95% (HPLC)

assay

≥97% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

DMSO: 5 mg/mL

solubility

DMSO: 10 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear (warmed)

color

white to beige

color

light yellow

color

white to beige

color

white to light brown


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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