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SML1401

XL413 hydrochloride

≥98% (HPLC), serine-threonine kinase CDC7 inhibitor, powder

Synonym(s):

(S)-8-Chloro-2-(pyrrolidin-2-yl)benzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride, BMS-863233, XL-413

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$233.00
$241.00
25 mg

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$731.00
$621.35

About This Item

Empirical Formula (Hill Notation):
C14H12ClN3O2 · xHCl
CAS Number:
Molecular Weight:
289.72 (free base basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated

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Product Name

XL413 hydrochloride, ≥98% (HPLC)

Quality Segment

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 5 mg/mL, clear

storage temp.

−20°C

SMILES string

ClC1=CC2=C(C=C1)OC3=C2N=C([C@H]4NCCC4)NC3=O.C

InChI

1S/C14H12ClN3O2.CH4/c15-7-3-4-10-8(6-7)11-12(20-10)14(19)18-13(17-11)9-2-1-5-16-9;/h3-4,6,9,16H,1-2,5H2,(H,17,18,19);1H4/t9-;/m0./s1

InChI key

UYBMDYGAVMHMGF-FVGYRXGTSA-N

Biochem/physiol Actions

XL413 is a selective inhibitor of the serine-threonine kinase CDC7 (cell division cycle 7 homolog), a regulator of cell cycle checkpoint control that has been implicated in protecting tumor cells from apoptotic cell death during replication stress. XL413 has an IC50 of 3.4 nM for CDC7, compared to 215 nM, 42 nM and 18 nM for CK2, PIM1 and pMCM2, respectively. XL413 caused significant tumor growth regression in rodent models, causing cell cycle arrest in the late S to G2 phase.
XL413 is a selective inhibitor of the serine-threonine kinase CDC7.

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This Item
SRP3274
description

≥98% (HPLC)

description

Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (SDS-PAGE), ≥98% (HPLC)

form

powder

form

lyophilized

Quality Level

100

Quality Level

-

storage temp.

−20°C

storage temp.

−20°C

storage condition

desiccated

storage condition

-

solubility

H2O: 5 mg/mL, clear

solubility

-


Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Codes

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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