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SML1403

IN-1130

≥98% (HPLC)

Synonym(s):

3-[[5-(6-Methyl-2-pyridinyl)-4-(6-quinoxalinyl)-1H-imidazol-2-yl]methyl]-benzamide, IN 1130

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Size/SKUAvailabilityPrice
25 mg

Available to ship TODAYfromMILWAUKEE

$660.00

About This Item

Empirical Formula (Hill Notation):
C25H20N6O
CAS Number:
Molecular Weight:
420.47
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$660.00


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

[nH]1c(nc(c1c4cc5nccnc5cc4)c3nc(ccc3)C)Cc2cc(ccc2)C(=O)N

InChI

1S/C25H20N6O/c1-15-4-2-7-20(29-15)24-23(17-8-9-19-21(14-17)28-11-10-27-19)30-22(31-24)13-16-5-3-6-18(12-16)25(26)32/h2-12,14H,13H2,1H3,(H2,26,32)(H,30,31)

InChI key

RYKSGWSKILPDDY-UHFFFAOYSA-N

Biochem/physiol Actions

IN-1130 is a potent inhibitor of the activin receptor-like kinase ALK-5 (Type 1 TGFβ1 recptor).
IN-1130 is a potent inhibitor of the activin receptor-like kinase ALK-5 (Type 1 TGF1β recptor). The compound inhibits phosphorylation of Smad-2 with an IC50 of 36 nM. IN-1130 inhibits renal fibrosis, and also reduces tumor volume in prostate tumor xenografts in murine models.

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This Item
681685
description

≥98% (HPLC)

description

A cell-permeable tyrphostin compound that acts as a partially selective deubiquitinase (DUB) inhibitor and suppresses JAK-Stat signaling pathway.

form

powder

form

solid

assay

≥98% (HPLC)

assay

≥97% (HPLC)

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 100 mg/mL

color

white to beige

color

light yellow


Pictograms

Exclamation mark

Signal Word

Warning

Hazard Codes

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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