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SML1404

A01 (Smurf1 inhibitor)

≥98% (HPLC)

Synonym(s):

[4-[[4-Chloro-3-(trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl][4-(5-methyl-1H-pyrazol-1-yl)phenyl]methanone

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Size/SKUAvailabilityPrice
5 mg
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$131.00
25 mg
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$509.00

About This Item

Empirical Formula (Hill Notation):
C22H20ClF3N4O3S
CAS Number:
Molecular Weight:
512.93
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$131.00


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

O=S(C1=CC=C(Cl)C(C(F)(F)F)=C1)(N2CCN(C(C3=CC=C(N4N=CC=C4C)C=C3)=O)CC2)=O

InChI

1S/C22H20ClF3N4O3S/c1-15-8-9-27-30(15)17-4-2-16(3-5-17)21(31)28-10-12-29(13-11-28)34(32,33)18-6-7-20(23)19(14-18)22(24,25)26/h2-9,14H,10-13H2,1H3

InChI key

QFYLTUDRXBNZFQ-UHFFFAOYSA-N

Biochem/physiol Actions

A01 is a high affinity selective inhibitor of E3 ubiquitin-protein ligase Smurf1 (Smad ubiquitination regulatory factor-1) that disturbs Smurf1-Smad1/5 interaction and blocks Smurf1 mediated Smad1/5 ubiquitination. A01 increases responsiveness to BMP-2 in myoblasts and osteoblasts.
A01 is a high affinity selective inhibitor of E3 ubiquitin-protein ligase Smurf1.

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This Item
SRP0227WH0057154M1HPA019671
description

≥98% (HPLC)

description

recombinant, expressed in baculovirus infected insect cells, ≥80% (SDS-PAGE)

description

clone 1D7, purified immunoglobulin, buffered aqueous solution

description

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

form

powder

form

aqueous solution

form

buffered aqueous solution

form

buffered aqueous glycerol solution

assay

≥98% (HPLC)

assay

≥80% (SDS-PAGE)

assay

-

assay

-

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−70°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

-

solubility

-

solubility

-

color

white to beige

color

-

color

-

color

-


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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