VE-821 has been used as an inhibitor of ATM- and Rad3-related (ATR) protein in human cancer cells.
Biochem/physiol Actions
VE-821 is a ATP-competitive inhibitor of ATR.
VE-821 is a potent ATP-competitive inhibitor of the DNA damage response (DDR) kinase Ataxia telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) with a Ki of 13 nM. VE-821 has minimal cross-reactivity against the related PIKKs ATM, DNA-dependent protein kinase (DNA-PK), mTOR and PI3-kinase-γ (Ki of 16 μM, 2.2 μM, >1 μM and 3.9 μM, respectively) and against a large panel of unrelated protein kinases. VE-821 used alone caused death in a large fraction of cancer cell populations and also showed strong synergy with genotoxic agents. VE-821 increased sensitivity of cells to radiation and also sensitized cancer cells to a variety of chemotherapeutic agents.
Other Notes
VE-821 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the VE-821 probe summary on the Chemical Probes Portal website.
NOTE: Both the cell line and DNA from the cell line may be available for this product. Please choose -1VL or VIAL for cells, or -DNA-5UG for DNA, 9100105, human lung, Epithelial
form
powder
form
powder
form
solid
form
-
assay
≥98% (HPLC)
assay
≥98% (HPLC)
assay
≥97% (HPLC)
assay
-
Quality Level
100
Quality Level
100
Quality Level
100
Quality Level
-
storage temp.
−20°C
storage temp.
2-8°C
storage temp.
−20°C
storage temp.
−196°C
solubility
DMSO: ≥10 mg/mL, clear
solubility
DMSO: >10 mg/mL
solubility
water: 25 mg/mL
solubility
-
color
white to beige
color
white to off-white
color
light yellow
color
-
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
Choose from one of the most recent versions:
Certificates of Analysis (COA)
Lot/Batch Number
It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.