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SML1443

L48H37

≥98% (HPLC)

Synonym(s):

(3E,5E)-1-ethyl-3,5-bis[(2,3,4-trimethoxyphenyl)methylidene]piperidin-4-one, 1-Ethyl-3,5-bis(3,4,5-trimethoxybenzylidene)piperidin-4-one, 1-Ethyl-3,5-bis[(2,3,4-trimethoxyphenyl)methylene]-4-piperidinone

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Size/SKUAvailabilityPrice
25 mg

Estimated to ship onOctober 12, 2026fromMILWAUKEE

$449.00

About This Item

Empirical Formula (Hill Notation):
C27H33NO7
CAS Number:
939318-04-4
Molecular Weight:
483.55
UNSPSC Code:
12352200
PubChem Substance ID:
329825883
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$449.00

Estimated to ship onOctober 12, 2026Details

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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

O=C(/C(CN(CC)C/1)=C/C2=C(OC)C(OC)=C(OC)C=C2)C1=C\C3=CC=C(OC)C(OC)=C3OC

InChI

1S/C27H33NO7/c1-8-28-15-19(13-17-9-11-21(30-2)26(34-6)24(17)32-4)23(29)20(16-28)14-18-10-12-22(31-3)27(35-7)25(18)33-5/h9-14H,8,15-16H2,1-7H3/b19-13+,20-14+

InChI key

XLPNFINERWLGNC-IWGRKNQJSA-N

Application

L48H37 has been used as a myeloid differentiator protein 2 (MD2) antagonist/inhibitor:
  • to investigate intracellular signaling of LPS in signal transduction pathways via endosomic toll-like receptor 4 (TLR4) in colonic epithelium
  • to determine its anti-cancer effects in pancreatic ductal adenocarcinoma (PDAC)
  • to study its effects on lipopolysaccharide (LPS) and palmitate CC chemokine ligand 2 (CCL2) responses in normal kidney proximal tubule cells

Biochem/physiol Actions

L48H37 is a potent and chemically stable anti-inflammatory curcumin analog that inhibits LPS-induced inflammation through the myeloid differentiation 2 (MD-2) and toll-like receptor 4 (TLR4) complex. L48H37 is a potent MD2 inhibitor that binds to the hydrophobic region of MD-2 and blocks the interaction between MD2 and LPS. L48H37 significantly improves survival and protected lung injury in LPS-induced septic mice.
L48H37 is a potent and chemically stable anti-inflammatory curcumin analog.
L48H37 can stimulate apoptosis and prevent proliferation in pancreatic cancer cells, especially in the absence of histone-lysine N-methyltransferase 2D (KMT2D). It has an unsaturated monoketone structure, which helps to enhance its stability and anti-cancer effects. L48H37 may possess an anti-neoplastic effect on human pancreatic ductal adenocarcinoma (PDAC) cells.

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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