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SML1449

G3335

≥98% (HPLC)

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Synonym(s):

H-Trp-Glu-OH, L-Tryptophyl-L-glutamic acid, WE

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Size/SKUAvailabilityPrice
250 mg
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$449.00

About This Item

Empirical Formula (Hill Notation):
C16H19N3O5
CAS Number:
Molecular Weight:
333.34
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$449.00

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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to off-white

storage temp.

−20°C

SMILES string

[nH]1c2c(c(c1)C[C@H](N)C(=O)N[C@@H](CCC(=O)O)C(=O)O)cccc2

InChI

1S/C16H19N3O5/c17-11(7-9-8-18-12-4-2-1-3-10(9)12)15(22)19-13(16(23)24)5-6-14(20)21/h1-4,8,11,13,18H,5-7,17H2,(H,19,22)(H,20,21)(H,23,24)/t11-,13-/m0/s1

InChI key

PWIQCLSQVQBOQV-AAEUAGOBSA-N

Biochem/physiol Actions

G3335 ( L-tryptophyl-L-glutamic acid) is a cell-permeable dipeptide that acts as a selective and reversible PPARγ antagonist with a Kd value of 8.34 μM for PPARγ and much lower activity at other PPAR subtypes. G3335 reversibly and competitively blocks activation of PPARγ by the PPARγ agonist rosiglitazone, and conversely, in rat astrocyte culture higher levels of rosiglitazone reduced harmful effects induced by G3335. At higher concentration G3335 may act as a PPARα agonist, interacting with the PPARα ligand binding domain with a KD of 120 μM. G3335 is reported to reduce hepatic lipid accumulation in lipid-loaded hepatocytes by activation of PPARα.
G3335 ( L-tryptophyl-L-glutamic acid) is a cell-permeable dipeptide that acts as a selective and reversible PPARγ antagonist.

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This Item
516566SML2820667307
description

≥98% (HPLC)

description

The PPARγ Antagonist III, G3335, also referenced under CAS 36099-95-3, controls the biological activity of PPARγ.

description

≥98% (HPLC)

description

98 atom % D

form

powder

form

solid

form

powder

form

solid

assay

≥98% (HPLC)

assay

≥98% (TLC)

assay

≥98% (HPLC)

assay

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

color

white to off-white

color

white

color

white to beige

color

-

H-Trp-Glu-OH chemical for research

-

-

-


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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